Earticle

초록

영어

Transforming growth factor-β (TGF-β) has been shown to have a positive effect on in vitro fertilization (IVF) and has been reported to stimulate meiosis at follicular level in variety of species. The study was designed to determine the expression patterns of TGF-β1, TGF-β receptors type Ⅰ, Ⅱ and Smads gene in bovine oocytes and embryos. TGF-β1 and their receptors were observed in the unfertilized oocytes. TGF-β1 and type Ⅱ receptor were not expressed at the blastocyst stage, however, only type I receptor was exclusively observed at the same stage. The blastocyst stage, in particular, showed high levels of mRNA expression patterns containing a TGF-β type Ⅰ receptor. The mRNA expression pattern of Smad 2 at all stages of embryonic development was similar in all respect with TGF-β1 type I receptor. On the contrary, Smad 3 and 4 were expressed with high and low level mRNA at the blastocyst stage. In conclusion, it is suggested that TGF-β signaling may be regarded as an important entity during the preimplantation embryo development.

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

키워드

저자

• Hak-Jae Chung [ Hak-Jae chung | Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea, Corresponding author ]
• Bong-Ki Kim [ Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea ]
• Jong-Mu Kim [ Department of Animal Science, Chungbuk National University, Cheongju 361-763, Korea ]
• Hyun-Gi Lee [ Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea ]
• Joo-Hee Han [ Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea ]
• Nam-Hyung Kim [ Department of Animal Science, Chungbuk National University, Cheongju 361-763, Korea ]
• Jin-Ki Park [ Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea ]
• Hwan-Hoo Seong [ Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea ]
• Boh Suk Yang [ Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea ]
• Won-Kyong Chang [ Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea ]
• Yeoung Gyu Ko [ Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea, Corresponding author ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Reproductive & developmental biology

• 간기

  계간

• pISSN

  1738-2432

• eISSN

  2288-0151

• 수록기간

  1977~2018

• 십진분류

  KDC 527 DDC 636