Earticle

초록

영어

Objective: To develop a population pharmacokinetics (PK)/pharmacodynamics (PD) model for alcohol in healthy volunteers and to elucidate individual characteristics to affects alcohol’s PK or PD including dissolved oxygen. Methods: Following multiple intakes of total 540 mL alcohol (19.42 v/v%) to healthy volunteer, blood alcohol concentration was measured using a Breathe alcohol analyser (Lion SD-400 Alcolmeter®). A sequential population PK/PD modeling was performed using NONMEM (ver 7.3). Results: Eighteen healthy volunteer were included in the study. PK model of alcohol was well explained by one-compartment model with first-order absorption and Michaelis-Menten elimination kinetics. Ka, V/F, Vmax, Km is 8.1 hr-1, 73.7 L, 9.65 g/hr, 0.041 g/L, respectively. Covariate analysis revealed that gender significantly influenced Vmax (Male vs Female, 9.65 g/hr vs 7.38 g/hr). PD model of temporary systolic blood pressure decreasing effect of alcohol was explained by biophase model with inhibitory Emax model. Ke0, Imax, E0, IC50 were 0.23 hr-1, 44.9 mmHg, 138 mmHg, 0.693 g/L, respectively. Conclusion: Model evaluation results suggested that this PK/PD model was robust and has good precision.

목차

ABSTRACT
 연구 방법
  피험자
  실험 기기 및 시료
  실험디자인
  알코올 투여
  혈중 알코올 농도 측정
  혈압검사
  집단 약물동태/약물동력 분석
  공변량 분석
  모델 평가(Model evaluation)
 연구 결과
  데이터 및 인구학적 특성
  최종 약물동태/약물동력 모델
 고찰 및 결론
 감사의 말씀(Acknowledgement)
 참고문헌

키워드

저자

• 송병정 [ Byungjeong Song | JW중외제약 신약연구센터 ]
• 백현문 [ Hyun-moon Back | 충남대학교 약학대학 임상약학연구실 ]
• 황시영 [ Si-young Hwang | 충남대학교 약학대학 임상약학연구실 ]
• 채정우 [ Chae Jung-woo | 충남대학교 약학대학 임상약학연구실 ]
• 윤휘열 [ Hwi-yeol Yun | 충남대학교 약학대학 임상약학연구실 ]
• 권광일 [ Kwang-il Kwon | 충남대학교 약학대학 임상약학연구실 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615