Earticle

초록

영어

Background: The effects of radiation on tissues vary depending on the radiation type. In this study, a minipig model was used to compare the effects of β-rays from 166Ho and γ-rays from 60Co on the skin. Materials and Methods: In this study, the detrimental effects of β- and γ-irradiation on the skin were assessed in minipigs. The histopathological changes in the skin from 1 to 12 weeks after exposure to 50 Gy of either β- (using 166Ho patches) or γ- (using 60Co) irradiation were assessed. Results and Discussion: The skin irradiated by β-rays was shown to exhibit more severe skin injury than that irradiated by γ-rays at 1-3 weeks post-exposure; however, while the skin lesions caused by β-rays recovered after 8 weeks, the γ-irradiated skin lesions were not repaired after this time. The observed histopathological changes corresponded with gross appearance scores. Seven days post-irradiation, apoptotic cells in the basal layer were detected more frequently in β-irradiated skin than in γ-irradiated skin. The basal cell density and skin thickness gradually decreased until 4 weeks after γ- and β- irradiation. In β-irradiated skin lesions, and the density and thickness increased sharply back to control levels by 6-9 weeks. However, this was not the case in γ-irradiated skin lesions. In γ-irradiated skin, cyclooxygenase-2 (COX-2) was shown to be expressed in the epidermis, endothelial cells of vessels, and fibroblasts, while β-irradiated lesions exhibited COX-2 expression that was mostly limited to the epidermis. Conclusion: In this study, β-rays were shown to induce more severe skin injury than γ-rays; however, the β-rays-induced injury was largely repaired over time, while the γ-rays-induced injury was not repaired and instead progressed to necrosis. These findings reveal the differential effects of γ- and β-irradiation on skin and demonstrate the use of minipigs as a beneficial experimental model for studying irradiation-induced skin damage.

목차

ABSTRACT
 Introduction
 Materials and Methods
  1. Animals
  2. Irradiation and sample biopsy
  3. Examination of clinicopathological alterations in gross appearance
  4. Histological examination
  5. Immunohistochemical study
  6. Statistical analysis
 Results and Discussion
 Conclusion
 Acknowledgements
 References

키워드

저자

• Joong-Sun Kim [ Lab. of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea; Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, Korea ]
• Hyosun Jang [ Lab. of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea ]
• Min-Ji Bae [ Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, Korea ]
• Sehwan Shim [ Lab. of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea ]
• Won-Seok Jang [ Lab. of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea ]
• Sun-Joo Lee [ Lab. of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea ]
• Sunhoo Park [ Lab. of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea ]
• Seung-Sook Lee [ Lab. of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  방사선방어학회지 [Journal of Radiation Protection and Research]

• 간기

  계간

• pISSN

  2508-1888

• 수록기간

  1976~2026

• 등재여부

  KCI 등재,SCOPUS

• 십진분류

  KDC 559 DDC 629