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The drinking effects of hydrogen water on alzheimer’s patient through oxidative stress and immune redox balance mechanism

첫 페이지 보기
  • 발행기관
    한국물학회 바로가기
  • 간행물
    한국물학회지 바로가기
  • 통권
    Vol.6 No.1 (2017.10)바로가기
  • 페이지
    pp.75-75
  • 저자
    Johny Bajgai, Kyu-Jae Lee
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A314386

원문정보

초록

영어
Hydrogen water (HW) produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on Alzheimer's disease (AD), type of dementia that is associated with cognitive impairment and memory loss, is poorly documented. In the present study, we investigated the drinking effects of hydrogen water on alzheimer’s patient for prevention of AD through oxidative stress and immuno redox mechanism. Alzheimer’s patients were administered with HW and purified water (PW) for 6 months. Further, we evaluated the drinking effect of hydrogen water on the cognitive impairment of AD patients by checking the serum concentration of AD biomarkers (Amyloid ; (A ) 40, 42 and tau), pro-β β inflammatory (IL-1β, IL-13), anti-inflammatory (IL-6, IL-10), macrophage activated Th1 (IL-2, IFN-γ, TNF-α, and IL-12p70), Th2 (IL-4, IL-5,) cytokines, reactive oxygen species (ROS) and nitric oxide (NO) level. We found that HW treatment significantly decrease the serum level of AD biomarker (Aβ- 40) during 6 month of treatment. In parallel, pro and anti-inflammatory cytokines were significantly inhibited in experimental group than control group. In line, macrophage activated TH1 cytokine, Th2 cytokines and ROS level were significantly decreased in HW than PW group. Likewise, HW treatment shows reduction in nitric oxide level than control group. Overall our clinical results strongly recommended that drinking hydrogen water might be a promising preventative approach for age-related neurodegenerative disease like AD and have an enormous impact on future healthcare for the elderly patients. This is the first note on the clinical application of drinking HW on the serum of AD patients.

키워드

Hydrogen water Alzheimer's disease AD biomarkers Anti-oxidant Cytokines Immuno redox marker

저자

  • Johny Bajgai [ Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do 220-701, Republic of Korea ]
  • Kyu-Jae Lee [ Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-do 220-701, Republic of Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국물학회 [The Korean Water Society]
  • 설립연도
    2010
  • 분야
    자연과학>생물학
  • 소개
    기능수관련연구 경영과 정보를 공유, 일본 중국기능수재단 협회전문가 초빙하여 학회와의 정보교류 기능수관련 학회 및 학술지를 발행하여 물관련연구정보교류에 목적을 두고 있음.

간행물

  • 간행물명
    한국물학회지 [Korean Journal of Waters]
  • 간기
    부정기
  • pISSN
    2233-4653
  • 수록기간
    2010~2021
  • 십진분류
    KDC 539 DDC 628

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