Earticle

초록

영어

This study was performed to evaluate anti-fatigue effect of hydrogen water (HW) drinking in chronic forced exercise mice model. Twelve-week old C57BL6 female mice were separated into non-stressed normal control (NC) group, and stressed group: purified water (PW)-treated group and HW treated group. Stress groups were supplied with PW and HW respectively ad libitum, and forced to swim for the stress induction every day for 4 consecutive weeks. Gross anti-fatigue effects of HW were assessed by swimming endurance capacity, metabolic activities, and immune-redox activities. Metabolic activities such as blood glucose, lactate, glycogen, and lactate dehydrogenase (LDH) as well as immune-redox activities such as reactive oxygen species (ROS), nitric oxide (NO), glutathione peroxidase (GPx), catalase, and the related cytokines were evaluated to elucidate underlying mechanism. HW group showed a higher swimming endurance capacity (p<0.001) than NC and PW groups. Positive metabolic effects in HW group were revealed by the significant reduction of blood glucose, lactate, and BUN after 4 weeks (p<0.01), as well as the significant increase of liver glycogen (p<0.001) and serum LDH (p<0.05). In parallel, redox balance was represented by lower ROS, NO (p<0.01), and increased level of GPx (p<0.05) and liver catalase (p<0.05) than PW group. In line, the decreased levels of TNF-α (p<0.01), IL-6 (p<0.001), and IL-23 (p<0.05) in HW group revealed positive cytokine profile compared to PW. This study shows anti-fatigue effects of hydrogen water (HW) drinking in chronic forced swimming mice via metabolic coordination and immune-redox balance. In that context, HW could be applied to the alternative and safety fluid remedy for chronic fatigue control.

키워드

저자

• Jesmin Ara [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University, Wonju 26426, Republic of Korea, Department of Global Medical Science, Wonju College of Medicine Yonsei University, Wonju 26426, Republic of Korea. ]
• AilynFadriquela [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University, Wonju 26426, Republic of Korea, Department of Global Medical Science, Wonju College of Medicine Yonsei University, Wonju 26426, Republic of Korea. ]
• MdFarukAhmed [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University, Wonju 26426, Republic of Korea, Department of Global Medical Science, Wonju College of Medicine Yonsei University, Wonju 26426, Republic of Korea. ]
• JohnyBajgai [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University, Wonju 26426, Republic of Korea, Department of Global Medical Science, Wonju College of Medicine Yonsei University, Wonju 26426, Republic of Korea. ]
• Ma Easter Joy Sajo [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University, Wonju 26426, Republic of Korea, Department of Global Medical Science, Wonju College of Medicine Yonsei University, Wonju 26426, Republic of Korea. ]
• Sung Pyo Lee [ Anydoctor HealthCare Co. Ltd. 234, Beotkkot-ro, Geumcheon-gu, Seoul 08513, Republic of Korea. ]
• Tae Su Kim [ Anydoctor HealthCare Co. Ltd. 234, Beotkkot-ro, Geumcheon-gu, Seoul 08513, Republic of Korea. ]
• Jinyoung Jung [ Mymirae Dermatology Clinic and Hydrogen Skin Research Institute, 7, Gukjegeumyung-ro 2- gil, Yeongdeungpo-gu, Seoul, Republic of Korea ]
• Cheol Su Kim [ Department of Microbiology, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea. ]
• Soo-Ki Kim [ Department of Microbiology, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea. ]
• Kwang Yong Shim [ Department of Internal Medicine, Wonju College of Medicine Yonsei University, Wonju 26426, Republic of Korea ] Corresponding author
• Kyu-Jae Lee [ Department of Environmental Medical Biology, Wonju College of Medicine Yonsei University, Wonju 26426, Republic of Korea, Institute for Poverty Alleviation and International Development, Yonsei University, 1 Yonseidae-gil, Wonju, Gangwon-do, 26493, Republic of Korea. ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국물학회지 [Korean Journal of Waters]

• 간기

  부정기

• pISSN

  2233-4653

• 수록기간

  2010~2021

• 십진분류

  KDC 539 DDC 628