Earticle

초록

영어

Neonates have large inter-individual variability in pharmacokinetic parameters of many drugs due to developmental differences. Theaim of this study was to investigate the factors affecting the pharmacokinetic parameters of drugs, which are commonly used incritically ill neonates. Factors that reflect physiologic maturation such as gestational age, postnatal age, postconceptional age, birthweight, and current body weight were correlated with pharmacokinetic parameters in neonates, especially preterm infants. Comorbiditycharacteristics affecting pharmacokinetics in critically ill neonates were perinatal asphyxia, hypoxic ischemic encephalopathy, patentductus arteriosus (PDA), and renal dysfunction. Administration of indomethacin or ibuprofen in neonates with PDA was associated withthe reduced clearance of renally excreted drugs such as vancomycin and amikacin. Therapeutic hypothermia and extracoporealmembrane oxygenation were influencing factors on pharmacokinetic parameters in critically ill neonates. Dosing adjustment and carefulmonitoring according to the factors affecting pharmacokinetic variability is required for safe and effective pharmacotherapy in neonatalintensive care unit.

목차

ABSTRACT
 본론
  신생아 특성인자
  신기능
  주산기 가사(perinatal asphyxia)
  저체온 치료(hypothermia)
  체외막산소화장치(extracorporeal membrane oxygenation)
  동맥관개존증
  병용 약물
  유전적 다형성
 결론
 참고문헌

키워드

저자

• 안숙희 [ Sook Hee An | 원광대학교 약학대학 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615