Earticle

초록

영어

Background: Acute radiation syndrome (ARS) primarily refers to damage to the hematopoietic system, myeloid system, and gastrointestinal (GI) system caused by radiation exposure. Such damage progresses to become life-threatening. In particular, as the syndrome develops very rapidly— within several hours from radiation exposure—prompt and accurate diagnosis and treatment are needed, as is further research into appropriate diagnostic and treatment modalities. Materials and Methods: Minipigs, which display human-like properties, underwent wholebody irradiation at 2 or 4 Gy (doses causing hematopoietic ARS) or at higher doses of 7 or 12 Gy. Changes in the blood cells and clinical symptoms were analyzed and we performed a necropsy when the animals succumbed to ARS. Results and Discussion: The minipig irradiated with 2 Gy showed a decrease in white blood cells, including neutrophils, lymphocytes, and platelets in the early stages. However, the blood cell counts gradually increased and returned to normal values. The minipig irradiated with 4 Gy succumbed due to hematopoietic ARS. In contrast, the minipigs irradiated with 7 or 12 Gy exhibited clinical symptoms of combined GI damage and hematopoietic syndrome. Moreover, a characteristic pattern of platelet changes was observed in the 7 and 12 Gy irradiated minipigs. Conclusion: The changes in the platelet count caused by radiation exposure observed in minipigs, which are hematologically and pathohistologically similar to humans, suggest that they can be used as a novel diagnostic criterion.

목차

ABSTRACT
 Introduction
 Materials and Methods
  1. Experimental animals and irradiation
  2. Variables observed and examined
 Results
  1. Clinical and pathological changes
  2. Hematological changes
  3. Histological changes
 Discussion and Conclusion
 Acknowledgements
 References

키워드

저자

• Hyosun Jang [ Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea ]
• Joong-sun Kim [ Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea; Research center, Dongnam Institute of Radiological and Medical Science, Busan, Korea ]
• Sehwan Shim [ Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea ]
• Won-seok Jang [ Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea ]
• Sun-Joo Lee [ Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea ]
• Jae Kyung Myung [ Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea ]
• Seung-Sook Lee [ Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea ]
• Sunhoo Park [ Laboratory of Radiation Exposure and Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  방사선방어학회지 [Journal of Radiation Protection and Research]

• 간기

  계간

• pISSN

  2508-1888

• 수록기간

  1976~2026

• 등재여부

  KCI 등재,SCOPUS

• 십진분류

  KDC 559 DDC 629