Earticle

초록

영어

Background: There is recent evidence that insulin resistance is responsible for increasing the risk of developing cognitive dysfunction. To systematically review the influence of intranasal insulin treatment on the cognitive function in Alzheimer’s disease patients. Methods: Randomized controlled trials comparing the cognitive effects of intranasal insulin therapy in Alzheimer’s disease patients with controlled interventions were retrieved from Pubmed, Medline, Embase and Cochrane library. Meta-analysis was conducted on the cognitive measurements with a subgroup analysis by dose, gender and apolipoprotein E allele 4 (ApoE ε4) status. Results: Seven randomized controlled trials were eligible for inclusion. Intranasal insulin had a positive influence on the cognitive function as compared to placebo without a statistical significance (standardized mean difference; SMD = 0.109; 95% confidence interval; CI -0.04 to 0.26; P=0.14). In subgroup analysis, a 20 IU dose of intranasal insulin induced a significant improvement in cognitive function (SMD = 0.14; 95% CI 0.05 to 0.24; P=0.004), but 40 IU did not show this effect (SMD = -0.01; 95% CI -0.11 to 0.09; P=0.82). ApoE ε4 positive patients showed a significant decline in cognitive function as compared to ApoE ε4 positive patients in the control group (SMD = -0.213; 95% CI -0.38 to -0.04; P=0.015). Such an effect was not apparent in ApoE ε4 negative patients. Gender had no influence on the cognitive outcomes. Conclusion: The results indicate that intranasal insulin may have beneficial effect in improving the cognitive function in Alzheimer’s disease patients.

목차

ABSTRACT
 METHODS
  Literature search, selection of studies, data extraction
  Risk of bias assessment
  Meta-analysis of the outcomes
 RESULTS
  Search results
  Study, patient, and intervention characteristics
  Risks of bias
  Effects of the intervention, meta-analysis
  Subgroup analysis by dose
  Subgroup analysis by gender
  Subgroup analysis by APOE ε4 status
  Safety outcomes
 DISCUSSION
  Major findings
  Quality of the findings
  Biases in this review
  Where our work stands?
  Limitations
 CONCLUSION
 CONFLICT OF INTEREST
 FUNDING
 REFERENCES

키워드

저자

• 사라 알라자르 [ Sarah Alnajjar | 이화여자대학교 대학원 생명ㆍ약학부 ]
• 진혜경 [ Hye Kyung Jin | 이화여자대학교 대학원 약학과 ]
• 강지은 [ Ji Eun Kang | 이화여자대학교 대학원 생명ㆍ약학부, 국립중앙의료원 약제부 ]
• 박소현 [ So Hyun Park | 이화여자대학교 대학원 생명ㆍ약학부 ]
• 이정연 [ Sandy Jeong Rhie | 이화여자대학교 대학원 생명ㆍ약학부 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615