Earticle

초록

영어

Obesity and chronic pain are two major diseases of the 21th century. Our principal objective was to investigate the effects of a 4-week reha-bilitation program on adiponectin and leptin concentrations, and insulin resistance, in patients with abdominal obesity and chronic pain syn-drome. Our secondary objectives were to investigate the effects of this program on pain, body mass index (BMI), waist circumference and maximal oxygen consumption (VO2max) and to compare changes in VO2m-ax between patients with or without insulin resistance. Among a con-secutive sample of 128 patients with abdominal obesity hospitalized for rehabilitation for a chronic pain syndrome, 111 completed the protocol, which was a 4-week rehabilitation program including 6 hr of rehabilita-tion per day, 5 days per week, in a referral center of rehabilitation. This prospective cohort study compared clinical (BMI, waist circumference, VO2max, pain) and biological measures (concentrations of adiponectin, leptin and insulin, score of homeostasis model assessment of insulin resistance [HOMA]) before and after the program. Plasma leptin, adi-ponectin and insulin concentrations (P<0.0001) and score of HOMA (P=0.0002) had decreased significantly by the end of the 4 weeks. Pain, BMI and waist circumference decreased significantly, and VO2max im-proved significantly (P=0.0001). Patients with insulin resistance had less improvement of their aerobic condition at the end of the 4 weeks (P<0.002). The rehabilitation program decreases the concentration of leptin, and improves insulin sensitivity in patients with chronic pain and visceral obesity. Aerobic recovery was worse for patients with insulin resistance than other patients.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Design
  Population
  Methods
  Subgroup analysis
  Statistical analysis
 RESULTS
  Population
  Adipokines and insulin resistance
  Clinical endpoints
  Subgroups analysis
 DISCUSSION
  Key results
  Study limitations
  Interpretation
  Chronic pain and obesity: what about clinical impacts?
  Clinical messages
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Florence Doury-Panchout [ CHU Tours, Service de Médecine Physique et Réadaptation, Tours, France ] Corresponding author
• Jean-Charles Metivier [ CHIC Amboise Château-Renault, Service de Médecine Physique et Réadaptation, Hôpital « Docteur Jean Delaneau » Rue Jules Joran, Château Renault, France ]
• Julien Nardoux [ CHU Tours, Service de Médecine Physique et Réadaptation, Tours, France, CHIC Amboise Château-Renault, Service de Médecine Physique et Réadaptation, Hôpital « Docteur Jean Delaneau » Rue Jules Joran, Château Renault, France ]
• Bernard Fouquet [ Fédération Universitaire Inter-Hospitalière de Médecine Physique et Réadaptation, CHU Tours, Tours, France ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613