Earticle

초록

영어

[PURPOSE] The purpose of this study was to assess the effect of swimming exercise in diabetic atrophy by monitoring changes in biomarkers associated with musculoskeletal growth and abnormalities. [METHODS] Ninety-two male Sprague-Dawley rats were randomly divided into four groups: control plus exercise group (CO+Ex), control and no exercise group (CO+No Ex), diabetes plus exercise group (DM+Ex) and diabetes and no exercise group (DM+No Ex). Swimming exercise was implemented for 60 min/day, 5 day/week for a total of eight weeks. Muscle strength and atrophy biomarkers as well as muscle morphology were compared at the first, second, fourth and eighth week of experimentation. [RESULTS] ACE levels were significantly higher in the DM groups (p<.05), however swimming exercise did not significantly affect ACE levels. Irisin levels were significantly higher in the DM and DM+Ex groups compared to the CON, in week one (p<.05), and greater in the DM+Ex group at week two compared to CON+Ex (p<.05), but swimming did not significantly affect irisin levels over the eight-week period in DM rats. In terms of muscle damage, Myl3 expression was unchanged in the CON groups, but significantly higher in the DM+Ex group compared to the CON+Ex group (p<.05). AST was found to be in higher levels in the DM+No Ex group, compared to CON and CON+Ex (p<.05); and DM+Ex group, compared to the CON+Ex group at weeks one, four and eight (p<.05). Tibialis anterior muscle fibers were thicker in the DM+Ex group compared to DM+No Ex, but only at week four (p<.05). Otherwise, no other notable differences were recorded in muscle morphology. [CONCLUSIONS] These results suggest that swimming exercise alone may not be sufficient to induce muscle strength and/or protective effects against muscle atrophy associated with diabetes mellitus. However, this mode of exercise may be considered safe by not compounding the deteriorative effects of this disease.

목차

ABSTRACT
 Introduction
 Methods
  Animal experiments
  Swimming exercise
  Streptozotocin-induced diabetic rats
  Measurement of growth factors and inflammatory factors
  Histological analysis
  Statistics
 Results
  Body weight, blood glucose levels, and muscle weight
  Muscle growth and damage factors
 Discussion
 Conclusions
 References

키워드

저자

• Youngsik Kim [ 김영식 | Kosin University ]
• Storm Reid [ Kyungsung University ]
• Eunkee Park [ 박은기 | Kosin University ]
• Yehchan Ahn [ 안예찬 | Pukyong National University ]
• Byeonghwan Jeon [ 전병환 | Kyungsung University ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  운동학 학술지 [HEALTH & SPORTS MEDICINE]

• 간기

  계간

• pISSN

  2092-6308

• eISSN

  2508-8653

• 수록기간

  1999~2017

• 십진분류

  KDC 517 DDC 613