Earticle

초록

영어

Postpartum depression (PPD) is defined as the depressive symptoms that occur from the moment of delivery until 12 months after delivery. PPD symptoms are closely associated with reduced activity of the se- rotonergic system. Serotonin (5-hydroxytryptamine, 5-HT) plays an im- portant role in the pathogenesis of depression. Tryptophan hydroxylase (TPH) catalyzes the rate-limiting step of 5-HT biosynthesis in the seroto-nergic neurons. Exercise exerts anti-depressive effect on depression patients as well as on animal models of depression. In the present study, the effect of treadmill exercise on PPD was investigated using rats. For this study, open field test for activity and forced swimming test for depressive symptoms, and immunohistochemistry for 5-HT and TPH were conducted. The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 2 weeks. Activity in the open field test was decreased in the postpartum rats, however, per- forming treadmill running increased activity in the postpartum rats. The climbing time was decreased and the immobility time was increased in the postpartum rats. Treadmill exercise increased climbing time and suppressed immobility time in the postpartum rats. 5-HT and TPH ex- pressions in the dorsal raphe were suppressed in the postpartum rats, and treadmill exercise enhanced 5-HT and TPH expressions in the postpartum rats. Treadmill exercise ameliorated the PPD very effective-ly by enhancing serotonin level.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Treadmill exercise protocol
  Open field test
  Forced swimming test
  Tissue preparation
  5-HT and TPH Immunohistochemistry
  Data analysis
 RESULTS
  Effect of treadmill exercise on the activity in the open field test
  Effect of treadmill exercise on the depressive behaviors in the forced swimming test
  Effect of treadmill exercise on the 5-HT expression in the dorsal raphe
  Effect of treadmill exercise on the TPH expression in the dorsal raphe
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Eun-Sang Ji [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Jae-Min Lee [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Tae-Woon Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• You-Mi Kim [ Department of Sport and Leisure Studies, Seonam University, Asan, Korea ]
• Yeon-Soo Kim [ Department of Sport and Leisure Studies, Seonam University, Asan, Korea ]
• Kijeong Kim [ School of Exercise & Sport Science, College of Natural Sciences, University of Ulsan, Ulsan, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613