Earticle

초록

영어

Objective: Infection is very common in the elderly, so there is a high prevalence of antibiotics use among this population. Especially, due to the emergence of resistant bacteria, the use of vancomycin is growing. The purpose of this study was to evaluate risk factors associated with vancomycin-induced nephrotoxicity in elderly patients. Methods: The subjects of this study were patients over 18 years old who received intravenous vancomycin in a general hospital located in Gangneung-si, Korea between August 1, 2013 and July 31, 2015. Data collection regarding vancomycin use and baseline characteristics was conducted using computerized hospital database. Logistic regression analysis was used to identify risk factors associated with vancomycin-induced nephrotoxicity. Results: A total of 290 patients were finally included, and 191(66%) out of these patients were age 65 or older. The incidence of vancomycin-induced nephrotoxicity was 11.0%, 12.6%, and 7.0% in the all adult patients, the elderly patients, and the non-elderly patients, respectively. There were significant differences in comorbidities between patients with nephrotoxicity and patients without nephrotoxicity in the all adult patients, and there were significant differences in vancomycin duration, comorbidities, and number of nephrotoxic agents between patients with nephrotoxicity and patients without nephrotoxicity in the elderly patients. However, according to the logistic regression analysis, there was no significant risk factor that increases the incidence of vancomycin-induced nephrotoxicity in all three age groups. Conclusion: There were no differences in risk factors that increase the incidence of vancomycin-induced nephrotoxicity between all adult patients, elderly patients, and non-elderly patients. Further studies with larger sample sizes to identify risk factors associated with vancomycin-induced nephrotoxicity in the elderly to improve the outcome of pharmacotherapy are required.

목차

ABSTRACT
 연구 방법
  연구 대상
  자료 수집 및 방법
  통계 분석
 연구 결과
  연구 대상자의 일반적 특성
  신독성 발생에 영향을 미치는 인자
 고찰 및 결론
 참고문헌

키워드

저자

• 김하늬 [ Ha Nui Kim | 강원대학교 약학대학 ]
• 김해숙 [ Hae Sook Kim | 강릉아산병원 약제팀 ]
• 이양현 [ Yang Hyun Lee | 강원대학교 약학대학 ]
• 이경주 [ Kyeong Ju Lee | 강원대학교 약학대학 ]
• 신승우 [ Seung Woo Shin | 강원대학교 약학대학, 강릉아산병원 약제팀 ]
• 박선철 [ Seon Cheol Park | 국민건강보험 일산병원 호흡기내과 ] Co-correspondence to
• 이유정 [ Yu Jeung Lee | 강원대학교 약학대학 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615