Earticle

초록

영어

The olfactory bulbectomy (OBX) is a well-known method inducing ani-mal model of depression. Depression is associated with dysfunction of serotonin (5-hydroxytryptamine, 5-HT) system. In the present study, an-tidepressive effect of treadmill exercise was investigated using olfacto-ry bulbectomized rats. After bilateral bulbectomy, the rats in the tread-mill exercise groups were subjected to run on a treadmill for 30 min once a day during 28 days. Increased immobility time and decreased fast time in the forced swim test were observed in the olfactory bulbec-tomized rats. Sucrose preference in the sucrose preference test was decreased and activity in the open field test was also increased in the olfactory bulbectomized rats. Treadmill exercise decreased immobility time and activity and increased fast time and sucrose preference in the olfactory bulbectomized rats. Expressions of 5-HT and tryptophan hy-droxylase (TPH) in the dorsal raphe of rats were suppressed by OBX and treadmill exercise increased the expressions of 5-HT and TPH in the olfactory bulbectomized rats. Serotonin receptor type 1A (5-HT1A) expression in the dorsal raphe was reduced by OBX and treadmill exer-cise increased 5-HT1A expression in the olfactory bulbectomized rats. In the present study, treadmill exercise ameliorated OBX-induced depres-sive symptoms. The antidepressive effect of treadmill exercise might be ascribed to the enhancement of serotonergic function through upregu-lation of 5-HT1A expression in the dorsal raphe.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals
  Bilateral OBX surgery
  Treadmill exercise protocol
  Forced swimming test
  Sucrose preference test
  Open field test
  Tissue preparation
  Immunohistochemistry for 5-HT and TPH expressions
  Western blot analysis for TPH and 5-HT1A expressions
  Statistical analysis
 RESULTS
  Effect of treadmill exercise on immobility and fasting time
  Effect of treadmill exercise on sucrose preference
  Effect of treadmill exercise on activity
  Effect of treadmill exercise on 5-HT and TPH expressions in the dorsal raphe
  Effect of treadmill exercise on TPH and 5-HT1A expressions in the dorsal raphe
 DISCUSSION
 CONFLICT OF INEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Mal-Soon Shin [ School of Global Sport Studies, Korea University, Sejong, Korea ]
• Sang-Seo Park [ School of Global Sport Studies, Korea University, Sejong, Korea ]
• Jae-Min Lee [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Tae-Woon Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Young-Pyo Kim [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613