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Analysis of fucosylation in liver-secreted N-glycoproteins from human hepatocellular carcinoma plasma using liquid chromatography with tandem mass spectrometry

첫 페이지 보기
  • 발행기관
    한국당과학회 바로가기
  • 간행물
    한국당과학회 학술대회 바로가기
  • 통권
    2017 한국당과학회 동계학술대회 (2017.01)바로가기
  • 페이지
    pp.69-69
  • 저자
    Eun Sun Ji, Heeyoun Hwang, Gun Wook Park, Ju Yeon Lee, Hyun Kyoung Lee, Na Young Choi, Hoi Keun Jeong, Kwang Hoe Kim, Jin Young Kim, Jong Shin Yoo
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A294827

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원문정보

초록

영어
Fucosylation of N-glycoproteins has been implicated in various diseases, such as hepatocellular carcinoma (HCC). However, few studies have performed site-specific analysis of fucosylation in liver-secreted proteins. In this study, we characterized the fucosylation patterns of liversecreted proteins in HCC plasma using a workflow to identify site-specific N-glycoproteins, where characteristic B- and/or Y-ion series with and without fucose in collision-induced dissociation were used in tandem mass spectrometry. In total, 71 fucosylated N-glycopeptides from 13 major liver-secreted proteins in human plasma were globally identified by LCMS/MS. Of the fucosylated N-glycopeptides, bi- and tri-antennary glycoforms were the most common ones identified in liver-secreted proteins from HCC plasma. Therefore, we suggest that this analytical method is effective for characterizing fucosylation in liver-secreted proteins.

저자

  • Eun Sun Ji [ Biomedical Omics Group, Korea Basic Science Institute, Ochang, Republic of Korea ]
  • Heeyoun Hwang [ Biomedical Omics Group, Korea Basic Science Institute, Ochang, Republic of Korea ]
  • Gun Wook Park [ Biomedical Omics Group, Korea Basic Science Institute, Ochang, Republic of Korea, Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Republic of Korea ]
  • Ju Yeon Lee [ Biomedical Omics Group, Korea Basic Science Institute, Ochang, Republic of Korea ]
  • Hyun Kyoung Lee [ Biomedical Omics Group, Korea Basic Science Institute, Ochang, Republic of Korea, Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Republic of Korea ]
  • Na Young Choi [ Biomedical Omics Group, Korea Basic Science Institute, Ochang, Republic of Korea, Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Republic of Korea ]
  • Hoi Keun Jeong [ Biomedical Omics Group, Korea Basic Science Institute, Ochang, Republic of Korea, Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Republic of Korea ]
  • Kwang Hoe Kim [ Biomedical Omics Group, Korea Basic Science Institute, Ochang, Republic of Korea, Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Republic of Korea ]
  • Jin Young Kim [ Biomedical Omics Group, Korea Basic Science Institute, Ochang, Republic of Korea ]
  • Jong Shin Yoo [ Biomedical Omics Group, Korea Basic Science Institute, Ochang, Republic of Korea, Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Republic of Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국당과학회 [Korean Society for Glycoscience]
  • 설립연도
    2006
  • 분야
    의약학>약학
  • 소개
    본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.

간행물

  • 간행물명
    한국당과학회 학술대회
  • 간기
    연간
  • 수록기간
    2006~2022
  • 십진분류
    KDC 517 DDC 614

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