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Characterization of Complex with Gene Based on Biopolymer and Peptides as Gene Carrier

첫 페이지 보기
  • 발행기관
    한국당과학회 바로가기
  • 간행물
    한국당과학회 학술대회 바로가기
  • 통권
    2017 한국당과학회 동계학술대회 (2017.01)바로가기
  • 페이지
    pp.50-50
  • 저자
    Eun-ji Kim, Young-min Kim, Nam-Hong Kim, Huk-Jin Seo, Seong-Cheol Park, Mi-Kyeong Jang
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A294808

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원문정보

초록

영어
In particular, cancer is one of major diseases in studies for gene delivery systems worldwide. Among them, breast cancer is a frequent malignancy worldwide and an important public health problem. In the past years, the molecular understanding of this disease has shed light into its heterogeneity. It is categorized into five groups: human epidermal growth factor receptor 2 [HER2] type, luminal A, luminal B, triple negative, and normal like, based on the cell surface and other molecular markers. The aim of this study is to improve transfection efficiency of gene carrier and to achieve targeted gene therapy for HER2-positive cancer cells, based on water-soluble chitosan (WSC) as a conjugating backbone biopolymer, synthetic peptides with Hexa-histidine-linear octa-arginine (HLR) or haxa-histidine-dendrimer octa-arginine (HDR) which is able to enhance nucleic acid-binding, proton sponge effect, and endosomal escape, LTVSPWY dendrimer peptide (Her2(d2)) which can target to HER2-positive cancer cells, and HnMc antimicrobial peptide which may be able to induce mitochondrial apoptosis.

저자

  • Eun-ji Kim [ Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea ]
  • Young-min Kim [ Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea ]
  • Nam-Hong Kim [ Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea ]
  • Huk-Jin Seo [ Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea ]
  • Seong-Cheol Park [ Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea ]
  • Mi-Kyeong Jang [ Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국당과학회 [Korean Society for Glycoscience]
  • 설립연도
    2006
  • 분야
    의약학>약학
  • 소개
    본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.

간행물

  • 간행물명
    한국당과학회 학술대회
  • 간기
    연간
  • 수록기간
    2006~2022
  • 십진분류
    KDC 517 DDC 614

이 권호 내 다른 논문 / 한국당과학회 학술대회 2017 한국당과학회 동계학술대회

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