Young-min Kim, Nam-Hong Kim, Eun-ji Kim, Huk-Jin Seo, Seong-Cheol Park, Mi-Kyeong Jang
언어
영어(ENG)
URL
https://www.earticle.net/Article/A294807
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원문정보
초록
영어
Gene therapy is the introduction of genes into cells or tissues to up- or down-regulate genes that can remove the pathological symptoms or activate the immune response via the delivery of DNA or RNA. This treatment has great promise for preventing or curing a wide range of diseases. In the present study, a RGD peptide and PEI grafted water soluble chitosan (RPgWSC) copolymer was synthesized and its efficiency as gene carrier investigated. The physiological characters, in vitro targeted gene transfection, cytotoxicity, blood-compatibility, and cellular distributions were investigated. In particular, a study of the endocytic mechanism resulted in the microtubule-dependent macropinocytosis and clathrin-mediated endocytosis.
저자
Young-min Kim [ Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea ]
Nam-Hong Kim [ Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea ]
Eun-ji Kim [ Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea ]
Huk-Jin Seo [ Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea ]
Seong-Cheol Park [ Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea ]
Mi-Kyeong Jang [ Department of Polymer Science and Engineering, College of Engineering, Sunchon National University, Sunchoeon, 57922, Korea ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.