Chang Won Lee, Jeong Yeon Seo, Sarang Cho, Seong Cheol Kim, Yong Il Park
언어
영어(ENG)
URL
https://www.earticle.net/Article/A294778
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원문정보
초록
영어
Recently, researches on plant polysaccharides have been increasingly important topics for the development of therapeutics for various diseases due to their multiple biological properties including anti-inflammation, wound healing, anti-hepatitis, anti-ulcer, and anti-neoplastic effects. The Camellia oleifera has been used extensively as cooking oil and traditionally applied as a medicine for stomachache and burning injury in China. The objectives of this study was to investigate the anti-osteoporotic effect and immunostimulating activity of Camellia oleifera polysaccharides (COP). Polysaccharides were isolated from the defatted C. oleifera seeds mainly by water extraction and 75% ethanol precipitation. Monosaccharide composition analysis by HPEAC-PAD showed that these polysaccharides consist of rhamnose, arabinose, galactose, glucose, and xylose as the major neutral sugars. COP was not toxic at up to 500 μg/ml in RAW 264.7 cells, and increased immunostimulating cytokines (TNF-α and IL-6) secretion in a dose-dependent manner. In addition, COP inhibited the receptor activator of NF-кB ligand (RANKL)-induced tartrate-resistance acid phosphatase (TRAP) activity and the formation of multinucleated osteoclasts. These results suggest that the COP may have potential anti-osteoporotic activity.
저자
Chang Won Lee [ Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea ]
Jeong Yeon Seo [ Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea ]
Sarang Cho [ Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea ]
Seong Cheol Kim [ Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea ]
Yong Il Park [ Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do 420-743, Republic of Korea ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.