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O-GlcNAc modification of Mef2c regulates C2C12 myoblast differentiation

첫 페이지 보기
  • 발행기관
    한국당과학회 바로가기
  • 간행물
    한국당과학회 학술대회 바로가기
  • 통권
    2016 한국당과학회 하계학술대회 (2016.07)바로가기
  • 페이지
    pp.41-41
  • 저자
    Han Byeol Kim, Jung Hwa Seo, Hyun Gyu Seo, Hyeonjin Choi, Byung Gyu Kim, Sang Yoon Park, Sunghoon Kim, Jaeyoung Pai, Injae Shin, Jin Won Cho
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A294759

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원문정보

초록

영어
O-GlcNAc modification is glycosylation that occurs on Serine and Threonine residues of proteins located in nucleus and cytoplasm. O-GlcNAcylation regulates various cellular events including transcription, translation, cell death and cell proliferation as cellular nutrient sensor. It also has important roles in development processes such as neurogenesis, osteogenesis, adipogenesis and myogenesis. Although some roles and molecular mechanism of O-GlcNAcylation in various development process has been studied, the relationship between O-GlcNAcylation and muscle differentiation is not clearly established. We confirm that physiological conditions to regulate cellular O-GlcNAc level as well as O-GlcNAcase inhibitor treatment influenced the myogenin expression and myogenesis. We also confirm that this results was shown in mouse model system. We demonstrate that these phenomenons result from O-GlcNAc of Mef2c. Furthermore, we identify the 3 O-GlcNAc sites in Mef2c and find that one of these site has role regulating the DNA binding affinity with promoter of myogenin. Our results suggest that one specific O-GlcNAc site of Mef2c is closely associated with muscle differentiation through the regulation of myogenin transcription.

저자

  • Han Byeol Kim [ Department of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University ]
  • Jung Hwa Seo [ Department of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University ]
  • Hyun Gyu Seo [ Department of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University ]
  • Hyeonjin Choi [ Functional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB) ]
  • Byung Gyu Kim [ Leading-edge Research Center for Drug Discovery and Development and Metabolic Disease, Kyungpook National University, Daegu, Korea ]
  • Sang Yoon Park [ Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892 ]
  • Sunghoon Kim [ Medicinal Bioconvergence Research Center Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science and Technology College of Pharmacy, Seoul National University. ]
  • Jaeyoung Pai [ Department of Chemistry, Yonsei University ]
  • Injae Shin [ Department of Chemistry, Yonsei University ]
  • Jin Won Cho [ Department of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국당과학회 [Korean Society for Glycoscience]
  • 설립연도
    2006
  • 분야
    의약학>약학
  • 소개
    본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.

간행물

  • 간행물명
    한국당과학회 학술대회
  • 간기
    연간
  • 수록기간
    2006~2022
  • 십진분류
    KDC 517 DDC 614

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