Most cancer cells need more glucose. Because they produce energy by fermentation, even though they exist in the presence of oxygen. Cancer cell can escape a poor environment like hypoxia and under nutrition condition. Considering this fact, It is deducible that hypoglycemia affect cancer metastasis. But the research about cancer metastasis has been limited to hypoxia condition until now. Interestingly, it was reported that O-GlcNAc modification on protein was increased under hypoglycemic condition. And it was thought that O-GlcNAcylation is related with EMT. In our study, we want to examine whether hypoglycemic condition can induce cancer metastasis and it is related to increased O-GlcNAc modification or not. So we focused on EMT to visualize cancer metastasis. We found that the amount of several EMT marker were changed under hypoglycemic condition in cancer cell. And it was mitigated by OGT knock down. These findings tell us that hypoglycemic condition can be closely connected with cancer metastasis via O-GlcNAclation. So we suggest possibilities that hypoglycemic condition induced EMT in cancer cell and it related with increased O-GlcNAc modification.
저자
Eunah Kim [ Department of Integrated OMICS for Biomedical Sciences, Graduate School, Yonsei University ]
Jin Won Cho [ Department of Integrated OMICS for Biomedical Sciences, Graduate School, Yonsei University ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.