Sung Youn Heo, Dong Hoon Kwak, Yu Na Seo, Won Seok Ju, Hyun Gyu Lim, Seo Yi Lee, Ji-Su Kim, Kyu-Tae Chang, Young-Kug Choo
언어
영어(ENG)
URL
https://www.earticle.net/Article/A294747
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원문정보
초록
영어
Mesenchymal stem cells can differentiate into multiple lineages depending on their exposure to differing biochemical and biomechanical inductive factors. The Ganglioside is included in biomarker, that are the major component of cytoplasmic cell membranes complex glycosphingolipids, and play a role in the control of biological processes. However, role of ganglioside in osteogenesis of mini-pig adipose derived mesenchymal stem cells (AD-MSCs) unclear . We have knocked down was ganglioside synthase UDP-glucose ceramide glucosyltransferase (UGCG)using a siRNA differentiation into osteoblast was markedly decreased in UGCG-knocked down AD-MSCs. The results showed significant inhibits alkaline phosphatase, osteocalcin, osteopontin, and Runt-related transcription factor 2 in UGCG knock down AD-MSCs compared to with the control AD-MSCs. Thus we guess, maybe ganglioside is essential factor to stimulate osteogenesis in AD-MSCs.
저자
Sung Youn Heo [ Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538 Korea ]
Dong Hoon Kwak [ Institute for Glycoscience, Wonkwang University, Iksan 570-749, Jeonbuk, Korea ]
Yu Na Seo [ Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538 Korea ]
Won Seok Ju [ Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538 Korea ]
Hyun Gyu Lim [ Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538 Korea ]
Seo Yi Lee [ Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538 Korea ]
Ji-Su Kim [ National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology(KRIBB), O-chang, chungbuk 363-883, Korea ]
Kyu-Tae Chang [ National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology(KRIBB), O-chang, chungbuk 363-883, Korea ]
Young-Kug Choo [ Department of Biological science, College of Natural Sciences, Wonkwang University, Institute for Glycoscience, Wonkwang University, Iksan 570-749, Jeonbuk, Korea ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.