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The Alteration of Ganglioside GD1a Expression in Swedish Mutation-Induced Alzheimer's Disease

첫 페이지 보기
  • 발행기관
    한국당과학회 바로가기
  • 간행물
    한국당과학회 학술대회 바로가기
  • 통권
    2016 한국당과학회 하계학술대회 (2016.07)바로가기
  • 페이지
    pp.28-28
  • 저자
    Won Seok Ju, Dong Hoon Kwak, Sung Youn Heo, Yu Na Seo, Hyun Gyu Lim, Seo Yi Lee, Ji-Su Kim, Kyu-Tae Chang, Young-Kug Choo
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A294746

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원문정보

초록

영어
Alzheimer's disease(AD), known as a chronic neurodegenerative disease, is the most common type of dementia with clinical symptoms. The pathogenesis of AD is highly believed to have a effect on the production and deposition of β-amyloid(Aβ) peptide. Swedish mutation or Familial Alzheimer’s disease genetic mutation is one of the most well known genetic variation that causes early onset familial AD. Gangliosides are key lipid molecules required for the regulation of cellular processes such as proliferation, differentiation and cell signaling. However the mechanism is not unclear between ganglioside and AD. This study was investigated relationship of gangliosides between ganglioside and AD. We made a cell line(WK-H4) using transformed Vector that is forced to gene over-expression of Aβ. We investigate the expression by using high performance thin-layer chromatograph(HPTLC), Western Blot(WB) and Immunofluoresence(IF). According to IF, the results show Aβ significantly increase in WK-H4. Also, HPTLC analysis shows that the expression of ganglioside GD1a is markedly diminished in WK-H4 than H4. Furthermore, β-Catenin at Wnt signal increases on WB analysis. While GSK-3β imperceptibly decrease in WK-H4. In conclusion, This study may reason out a conclusion that ganglioside is associated with AD and the selective control of ganglioside is helpful treatment of AD as a fresh bio-marker.

저자

  • Won Seok Ju [ Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea ]
  • Dong Hoon Kwak [ Institute for Glycoscience, Wonkwang University, Iksan 570-749, Jeonbuk, Korea ]
  • Sung Youn Heo [ Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea ]
  • Yu Na Seo [ Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea ]
  • Hyun Gyu Lim [ Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea ]
  • Seo Yi Lee [ Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea ]
  • Ji-Su Kim [ National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology(KRIBB), O-chang, chungbuk 363-883, Korea ]
  • Kyu-Tae Chang [ National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology(KRIBB), O-chang, chungbuk 363-883, Korea ]
  • Young-Kug Choo [ Department of Biological science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 570-749, Korea, Institute for Glycoscience, Wonkwang University, Iksan 570-749, Jeonbuk, Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국당과학회 [Korean Society for Glycoscience]
  • 설립연도
    2006
  • 분야
    의약학>약학
  • 소개
    본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.

간행물

  • 간행물명
    한국당과학회 학술대회
  • 간기
    연간
  • 수록기간
    2006~2022
  • 십진분류
    KDC 517 DDC 614

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