Earticle

초록

영어

Human milk oligosaccharides (HMOs) are a family of structurally diverse unconjugated glycans that are highly abundant in human milk. HMOs consisted of 3 to 22 monosaccharides can either be linear or branched. HMOs play an essential role in biological functions such as immune maturation, organ development, and healthy microbial colonization. The biosynthesis and the structure–specific biological role of HMOs is still conundrum. To advance the functional understanding of HMOs, the identification and quantification of them is of great importance. Characterization of Caucasian HMOs has reported, however, structure-specific characterization of Korean HMOs has not been investigated. In this study, we have performed in-depth characterization of Korean-specific HMOs from 22 mothers. By combining rapid MALDI-MS profiling with detailed structural interrogation by nano-LC-MS and MS/MS, Korean HMOs were analyzed. More than sixty HMOs were identified, corresponding to over thirty glycan compositions. Major twenty HMOs were structurally elucidated by CID tandem MS. Interestingly, we found that a few HMOs are presented in only Korean HMOs. Our study is first approach for Korean-specific HMOs and can serve as a recommendation for the artificial nutrition industry for baby formula. Furthermore, creation of the Korean HMOs database would support promoting health.

저자

• Nari Seo [ Graduate School of Analytical Science and Technology (GRAST), Chungnam National University, Asia-Pacific Glycomics Reference Site ]
• Jae Han Kim [ Department of Food and Nutrition, Chungnam National University ]
• Hyun Joo An [ Graduate School of Analytical Science and Technology (GRAST), Chungnam National University, Asia-Pacific Glycomics Reference Site ]

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발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국당과학회 학술대회

• 간기

  연간

• 수록기간

  2006~2022

• 십진분류

  KDC 517 DDC 614