Jin Yeon Park, So Hee Loh, Eun Hee Cho, Young Sun Kang
언어
영어(ENG)
URL
https://www.earticle.net/Article/A294704
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원문정보
초록
영어
Although SIGN-R1-mediated complement activation pathway has been shown to enhance the systemic clearance of apoptotic cells, the role of SIGN-R1 in the clearance of radiation-induced apoptotic cells has not been characterized and was investigated in this study. Our data indicated that whole-body ɤ-irraiation of mice increased caspase-3+ apoptotic lymphocyte numbers in secondary lymphoid organs. Following ɤ-irradiation, SIGN-R1 and complement (C4 and C3) were simultaneously increased only in the mice spleen tissue among the assessed tissues. In particular, C3 was exclusively acrivated in the spleen. The delayed clearance of apoptotic cells was markedly prevalent in the spleen and liver of SIGN-R1 KO mice, followed by a significant increase of CD11b+ cells. These results indicate that SIGN-R1 and complement factors play an important role in the systemic clearance of radiation-induced apoptotic innate immune cells to maintain tissue homeostasis after ɤ-irradiation.
저자
Jin Yeon Park [ Department of Biomedical Science & Technology, Konkuk University ]
So Hee Loh [ Department of Biomedical Science & Technology, Konkuk University ]
Eun Hee Cho [ Department of Biomedical Science & Technology, Konkuk University ]
Young Sun Kang [ Department of Biomedical Science & Technology, Konkuk University ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.