Polymeric nanoparticles based on natural polymer have been investigated due to low cytotoxicity, biocompatibility, and non-immunogenicity. In particular, chitosan has many advantages in this regard, but has to overcome the obstacles such as low bioavailability and gene expression level. For this object, ligand molecules binding with targeting receptors which are overexpressed in pathogen or tumor cells provides immense opportunities for the concentrative delivery of bioactive cargos into targeting cells and the minimum toxicity in normal cells. Therefore the conjugation of a pathogenic cell-specific ligand molecules to polymeric nanoparticles is an important strategy in the design of drug delivery carrier. The present studies describe a notable use of antifungal peptide as targeting ligand toward fungal pathogen and the applications of new ligands in tumor gene therapy.
저자
Nam-Hong Kim [ Department of Polymer Science and Engineering, Sunchon National University ]
Seong-Chul Park [ Department of Polymer Science and Engineering, Sunchon National University ]
Mi-Kyeong Jang [ 장미경 | Department of Polymer Science and Engineering, Sunchon National University ]
본 학회는 화학, 생화학, 분자생물학, 미생물학, 식품공학, 의학, 약학, 유전공학 및 생물공학, 환경 및 기타 공업 등 전 분야의 탄수화물관련 이론과 기술을 연구 발전시키고 산학협동을 통해 이를 보급하여 국내 관련 산업의 발전 및 국민생활의 과학화에 기여하고자 하며, 이러한 목표와 비젼의 실현을 위해 회원들이 적극적인 참여와 활동을 전개하고자 한다.