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Whitening effect of Ganoderma lucidum on B16F10 melanoma cells

첫 페이지 보기
  • 발행기관
    한국버섯학회 바로가기
  • 간행물
    버섯 바로가기
  • 통권
    제20권 1호 통권 33호 (2016.06)바로가기
  • 페이지
    pp.208-208
  • 저자
    Ji-Woong Kim, Jong-Hyeon Kim, Hong-Il Kim, O-Chul Kwon, Chang-Soo Lee, Young-Jin Park
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A289403

원문정보

초록

영어
Ganoderma lucidum, a species of the class Basidiomycetes, attracts international attention due to the wide variety of its biological activities and great potential as cosmetic ingredient, such as skin care cosmetics including ‘skin-whitening’. However, there is little information available regarding the tyrosinase inhibitory activity. Therefore, the objectives of this study were to investigate the chemical composition and tyrosinase inhibitory activity of the G. lucidum. To isolate active single compound from G. lucidum (GASC), we conducted ethanol extraction and chloroform fractionation. In addition, we assayed the inhibitoty effect of tyrosinase activity and melanin biosynthesis in B16F10 mouse melanoma cells. In the present study, we identified a GASC, which exhibited inhibitory effects of cellular tyrosinase activity, the protein expression of cellular tyrosinase and tyrosinase-related protein-1, 2. In additional, microphthalmia-associated transcription factor (MITF), as known as crucial regulator of melanogenesis-related genes, was down-regulated by treatment with GASC in a concentration-dependent manner. GASC exhibited significant inhibition of tyrosinase activity and melanin synthesis in B16F10. The finding that melanogenesis inhibitory effect of GASC will contribute to facilitate various approaches of this mushroom for use in skin whitening products.

저자

  • Ji-Woong Kim [ Department of Biomedical Chemistry, Konkuk University, Chungju, Korea ]
  • Jong-Hyeon Kim [ Department of Biomedical Chemistry, Konkuk University, Chungju, Korea ]
  • Hong-Il Kim [ Department of Biomedical Chemistry, Konkuk University, Chungju, Korea ]
  • O-Chul Kwon [ Department of Biomedical Chemistry, Konkuk University, Chungju, Korea ]
  • Chang-Soo Lee [ Department of Biomedical Chemistry, Konkuk University, Chungju, Korea ]
  • Young-Jin Park [ Department of Biomedical Chemistry, Konkuk University, Chungju, Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국버섯학회 [The Korean Society of Mushroom Science]
  • 설립연도
    1997
  • 분야
    농수해양>농학
  • 소개
    우리나라의 버섯 연구와 관련 산업의 발전에 기여하고 버섯관련 연구자와 관련산업 종사자간의 학술정보 등의 교류를 목적으로 한다.

간행물

  • 간행물명
    버섯 [Mushroom]
  • 간기
    반년간
  • 수록기간
    1997~2025
  • 십진분류
    KDC 525 DDC 635

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