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Pleurotus cornucopiae enhances osteoblastic differentiation with increased expression of Id-1 and Id-2 in pre-osteoblast cell line, MC3T3-E1

첫 페이지 보기
  • 발행기관
    한국버섯학회 바로가기
  • 간행물
    버섯 바로가기
  • 통권
    제20권 1호 통권 33호 (2016.06)바로가기
  • 페이지
    pp.203-203
  • 저자
    Young-Ock Kim, Chun-Geon Park, Kang-Hyo Lee, Won-Sik Kong, Kyung-Hun Park, Hyung-Don Kim, Yu-Su Shin, Chan-Heum Park, Ji-Yeon Lee, Young Sub Ahn
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A289391

원문정보

초록

영어
Pleurotus cornucopiae (PC) mushrooms is found in the field and commonly known in Japan as Tamogidake mushrooms. Recently it has been reported that PC also alleviating the toxicity of heavy metals. However little is known about mechanism of the action of PC on osteoblast differentiation, especially in transcription factor. Inhibitor of DNA binding-1 (Id-1) function has been linked to the proliferation, migration, and senescence of cells, and studies about relationship between Id-1 and biological function. Therefore, this study was aimed to investigate the effect of PC on osteoblast differentiation and expression of Id-1 and Id-2. PC treatment increased ALP, Col 1 and OCN. PC treatment up-regulated the mRNA levels of Id-1 and Id-2 genes. This PC–induced osteoblast differentiation is more effective in lower doses rather than high doses. This study shows that expression of Id-1 and Id-2 was increased in a dose-dependent manner during PC-induced osteoblast differentiation.

저자

  • Young-Ock Kim [ Department of Herbal Crop Research, NIHHS, RDA ]
  • Chun-Geon Park [ Department of Herbal Crop Research, NIHHS, RDA ]
  • Kang-Hyo Lee [ Department of Herbal Crop Research, NIHHS, RDA ]
  • Won-Sik Kong [ Department of Herbal Crop Research, NIHHS, RDA ]
  • Kyung-Hun Park [ Department of Herbal Crop Research, NIHHS, RDA ]
  • Hyung-Don Kim [ Department of Herbal Crop Research, NIHHS, RDA ]
  • Yu-Su Shin [ Department of Herbal Crop Research, NIHHS, RDA ]
  • Chan-Heum Park [ Department of Herbal Crop Research, NIHHS, RDA ]
  • Ji-Yeon Lee [ Department of Herbal Crop Research, NIHHS, RDA ]
  • Young Sub Ahn [ Department of Herbal Crop Research, NIHHS, RDA ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국버섯학회 [The Korean Society of Mushroom Science]
  • 설립연도
    1997
  • 분야
    농수해양>농학
  • 소개
    우리나라의 버섯 연구와 관련 산업의 발전에 기여하고 버섯관련 연구자와 관련산업 종사자간의 학술정보 등의 교류를 목적으로 한다.

간행물

  • 간행물명
    버섯 [Mushroom]
  • 간기
    반년간
  • 수록기간
    1997~2025
  • 십진분류
    KDC 525 DDC 635

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