Earticle

초록

영어

Autism is a complex developmental disorder with impairments in social interaction, communication, repetitive behavior and motor skills. Exer-cise enhances cognitive function, ameliorates motor dysfunction, and provides protective profits against neurodegeneration. In the present study, we evaluated the effect of treadmill exercise on the motor coor-dination and Purkinje cell loss in relation with reactive astrocytes and microglial activation in the cerebellum using valproic acid (VPA)-in-duced autism rat model. On the 12th day of pregnancy, the pregnant rats in the VPA-exposed group received intraperitoneal injections of 600-mg/kg VPA. After birth, the rat pups were divided into four groups: the control group, the exercise group, the VPA-treated group, the VPA- treated and exercise group. The rat pups in the exercise groups were forced to run on a treadmill for 30 min once a day, 5 times a week for 4 weeks. In the present results, motor balance and coordination was dis-turbed by induction of autism, in contrast, treadmill exercise alleviated motor dysfunction in the autistic rats. Purkinje cell loss, reactive astro-cytes, and microglial activation were occurred by induction of autism, in contrast, treadmill exercise enhanced survival rate of Purkinje neu-rons through inhibition of reactive astrocytes and microglia in the autis-tic rats. The present study showed that exercise may provide a potential therapeutic strategy for the alleviation of motor dysfunction in autistic patients.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Treadmill exercise protocol
  Rota-rod test
  Tissue preparation
  Immunohistochemistry
  Western blotting
  Data analysis
 RESULTS
  Effect of treadmill exercise on the motor function in the rota-rod test
  Effect of treadmill exercise on Purkinje neurons in the cerebellar vermis
  Effect of treadmill exercise on reactive astrocytes in the cerebellar vermis
  Effect of treadmill exercise on reactive astrocytes in the cerebellum
  Effect of treadmill exercise on microglial activation in the cerebellum
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Han-Sam Cho [ Department of Sport & Health Science, College of Natural Science, Sangmyung University, Seoul, Korea ]
• Tae-Woon Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Eun-Sang Ji [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Hye-Sang Park [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Mal-Soon Shin [ School of Sports and Leisure Studies, Korea University, Sejong, Korea ]
• Seung-Soo Baek [ Department of Sport & Health Science, College of Natural Science, Sangmyung University, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613