Earticle

초록

영어

Spinal cord injury (SCI) disrupts both axonal pathways and segmental spinal cord circuity, resulting in permanent neurological deficits. Physi-cal exercise is known to increase the expression of neurotrophins for improving the injured spinal cord. In the present study, we investigated the effects of treadmill exercise on locomotor function in relation with brain-derived neurotrophic factor (BDNF) expression after SCI. The rats were divided into five groups: control group, sham operation group, sham operation and exercise group, SCI group, and SCI and exercise group. The laminectomy was performed at the T9–T10 level. The ex-posed dorsal surface of the spinal cord received contusion injury (10 g × 25 mm) using the impactor. Treadmill exercise was performed 6 days per a week for 6 weeks. In order to evaluate the locomotor function of animals, Basso-Beattie-Bresnahan (BBB) locomotor scale was con-ducted once a week for 6 weeks. We examined BDNF expression and axonal sprouting in the injury site of the spinal cord using Western blot analysis and immunofluorescence staining. SCI induced loss of loco-motor function with decreased BDNF expression in the injury site. Treadmill exercise increased the score of BBB locomotor scale and re-duced cavity formation in the injury site. BDNF expression and axonal sprouting within the trabecula were further facilitated by treadmill exer-cise in SCI-exposed rats. The present study provides the evidence that treadmill exercise may facilitate recovery of locomotor function through axonal regeneration via BDNF expression following SCI.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Surgical procedures
  Treadmill exercise protocol
  BBB locomotor scale
  Tissue preparation
  Hematoxylin and eosin staining
  Immunofluorescence
  Western blot analysis
  Data analysis
 RESULTS
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Sun-Young Jung [ Department of Physical Therapy, Hosan University, Gyeongsan, Korea ]
• Tae-Beom Seo [ Division of Sports Science and Engineering, Korea Institute of Sports Science, Seoul, Korea ]
• Dae-Young Kim [ Department of Sports Health Care, College of Humanities & Social Sciences, Inje University, Gimhae, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613