Earticle

초록

영어

High-intensity eccentric exercise is known to induce muscle damage leading to inflammatory responses and extracellular matrix (ECM) deg-radation. These degradation processes involve enzymes such as matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs). MMPs are calcium and zinc-dependent proteolytic enzymes that play a role in ECM degradation and recruitment of inflammatory and myogenic cells into the damaged site. In contrast, TIMPs inhibit MMP-induced ECM degradation to maintain normal homeostasis in ECM. Recently, several studies have examined the process of muscle remodeling and the roles of ECM, MMPs, and TIMPs in exercise-in-duced muscle damage. However, the results of these studies are not in-consistent. In the present mini-review, we will discuss the responses of MMP and TIMP to eccentric exercise based on the literature review.

목차

Abstract
 INTRODUCTION
 MATRIX METALLOPROTEINASE IN SKELETAL MUSCLE
 TISSUE INHIBITOR OF METALLOPROTEINASE IN SKELETAL MUSCLE
 MATRIX METALLOPROTEINASE AND TISSUE INHIBITOR OF METALLOPROTEINASE RESPONSES TO ECCENTRIC EXERCISE
 CONCLUSIONS
 CONFLICT OF INTEREST
 REFERENCES

키워드

저자

• Jooyoung Kim [ Sport, Health, and Rehabilitation Major, Kookmin University, Seoul, Korea ]
• Joohyung Lee [ Sport, Health, and Rehabilitation Major, Kookmin University, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613