Earticle

초록

영어

Background: This study investigated the effects of zoledronic acid (ZA) on radiation-induced bone loss in C3H/HeN mice. Materials and Methods: C3H/HeN mice were divided into sham control and three irradiated groups (3 Gy, gamma ray). The irradiated mice were treated for 12 weeks with vehicle, amifostine (intraperitoneal injection), or ZA (subcutaneous injection). Grip strength, uterus weight, and serum alkaline phosphatase (ALP), and tartrate-resistant acid phosphatase (TRAP) levels were measured. Tibiae were analyzed using micro-computed tomography. Results and Discussion: Treatment of ZA (100 μg·kg-1 ·week-1) significantly preserved trabecular bone volume, trabecular thickness, trabecular number, trabecular separation, bone mineral density of proximal tibia metaphysic, and cortical bone volume, but did not alter the uterus weight of the mice. The administration of ZA for 12 weeks lowered serum ALP and TRAP levels in irradiated mice, suggesting that ZA can reduce the bone turnover rate in mice. No differences were apparent between the amifostine-treated group and the irradiation control group. Conclusion: The results indicate that ZA can prevent radiation-induced bone loss in mice.

목차

ABSTRACT
 Introduction
 Materials and Methods
  1. Animals and irradiation
  2. Treatment groups and chemical treatment
  3. Measurement of grip strength, study endpoint, and serum analyses
  4. Micro-computed tomography (micro-CT)
  5. Statistical analysis
 Results and Discussion
 Conclusion
 Acknowledgments
 References

키워드

저자

• Jinwook Kim [ College of Veterinary Medicine, Chonnam National University, Gwangju ]
• Sueun Lee [ College of Veterinary Medicine, Chonnam National University, Gwangju ]
• Sohi Kang [ College of Veterinary Medicine, Chonnam National University, Gwangju ]
• Changjong Moon [ College of Veterinary Medicine, Chonnam National University, Gwangju ]
• Jong-Choon Kim [ College of Veterinary Medicine, Chonnam National University, Gwangju ]
• Uhee Jung [ Advanced Radiation Technology Institute, Jeungeup ]
• Sung-Kee Jo [ Advanced Radiation Technology Institute, Jeungeup ]
• Jong-Sik Jang [ College of Ecology and Environmental Science, Kyungpook National University, Sangju, Korea ]
• Sung-Ho Kim [ College of Veterinary Medicine, Chonnam National University, Gwangju ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  방사선방어학회지 [Journal of Radiation Protection and Research]

• 간기

  계간

• pISSN

  2508-1888

• 수록기간

  1976~2026

• 등재여부

  KCI 등재,SCOPUS

• 십진분류

  KDC 559 DDC 629