Earticle

초록

영어

Background: Ionizing radiation causes cellular damage and death through the direct damage and/or indirectly the production of ROS, which induces oxidative stress. This study was designed to evaluate the in vivo radioprotective effects of a bio-active material coated fabric (BMCF) against γ-irradiation-induced cellular damage in Sprague-Dawley (SD) rats. Materials and Methods: Healthy male SD rats wore bio-active material coated (concentrations in 10% and 30%) fabric for 7 days after 3 Gy of γ-irradiation. Radioprotective effects were evaluated by performing various biochemical assays including spleen and thymus index, WBC count, hepatic damage marker enzymes [aspartate transaminase (AST) and alanine transaminase (ALT)] in plasma, liver antioxidant enzymes, and mitochondrial activity in muscle. Results and Discussions: Exposure to γ-irradiation resulted in hepatocellular and immune systemic damage. Gamma-irradiation induced decreases in antioxidant enzymes. However, wearing the BMCF-30% decreased significantly AST and ALT activities in plasma. Furthermore, wearing the BMCF-30% increased SOD (superoxide dismutase) and mitochondrial activity. Conclusion: These results suggest that wearing BMCF offers effective radioprotection against γ-irradiation-induced cellular damage in SD rats.

목차

ABSTRACT
 Introduction
 Materials and Methods
  1. BMCF
  2. Animals
  3. Experimental design and irradiation
  4. Blood and tissue collection
  5. Determination of WBC, RBC, platelet, AST, and ALT concentrations
  6. Evaluation of oxidative stress and antioxidant defense system
  7. Mitochondrial activity
  8. Statistical analysis
 Results and Discussion
  1. Effects of wearing BMCF on body weight, spleen, and thymus indexes
  2. Effects of wearing BMCF on hematology
  3. Effects of wearing BMCF on hepatocellular damage
  4. Effects of wearing BMCF on antioxidant defense system in liver tissue
  5. Effects of wearing BMCF on mitochondrial activity in muscle
 Conclusion
 Acknowledgement
 References

키워드

저자

• Jung Ae Kang [ Korea Atomic Energy Research Institute, Jeongeup ]
• Hye Rim Kim [ Korea Atomic Energy Research Institute, Jeongeup ]
• Sunhye Yoon [ Korea Atomic Energy Research Institute, Jeongeup ]
• You Ree Nam [ Korea Atomic Energy Research Institute, Jeongeup ]
• Sang Hyun Park [ Korea Atomic Energy Research Institute, Jeongeup, Department of Radiation Biotechnology and Applied Radioisotope Science, Korea University of Science and Technology, Daejeon ]
• Kyung-Chan Go [ Research and Development Center, VENTEX Co. Ltd., Seoul, Korea ]
• Gwang-Wung Yang [ Research and Development Center, VENTEX Co. Ltd., Seoul, Korea ]
• Young-Hwan Rho [ Research and Development Center, VENTEX Co. Ltd., Seoul, Korea ]
• Hyo-Suk Park [ Research and Development Center, VENTEX Co. Ltd., Seoul, Korea ]
• Beom Su Jang [ Korea Atomic Energy Research Institute, Jeongeup, Department of Radiation Biotechnology and Applied Radioisotope Science, Korea University of Science and Technology, Daejeon ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  방사선방어학회지 [Journal of Radiation Protection and Research]

• 간기

  계간

• pISSN

  2508-1888

• 수록기간

  1976~2026

• 등재여부

  KCI 등재,SCOPUS

• 십진분류

  KDC 559 DDC 629