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인삼이 혈압에 미치는 영향 : 체계적 문헌고찰 및 메타분석
Effect of Ginseng on Blood Pressure : A Systematic Review and Meta-Analysis
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- 발행기관
- 한국임상약학회 바로가기
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- 간행물
- 한국임상약학회지 KCI 등재 바로가기
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- 통권
- 제26권 제2호 (2016.06)바로가기
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- 페이지
- pp.163-171
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A278905
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초록
- 영어
- Objective: A meta-analysis was performed to determine effect of ginseng on blood pressure. Methods: The databases of PubMed, Embase, Cochrane Library, RISS, DBpia, KISS, and Koreamed were searched for all published studies from inception to January 2016. The following terms were used: “ginseng”, “hypertension”, and “blood pressure”. Using the Review Manager 5, mean differences (MDs) were pooled to measure the effect of ginseng on blood pressure compared to that of placebo. Results: Eleven randomized controlled trials were included. In this meta-analysis, ginseng treatment significantly lowered systolic blood pressure (SBP) in a dose-independent way (MD: −1.99, p = 0.04). In subgroup analysis, 8-12 week consumption of ginseng achieved significantly greater reduction in SBP (MD: −3.14, p = 0.03), while single administration of ginseng failed to show BP-lowering effect. When ingested over 8-12 weeks, ginseng significantly lowered diastolic blood pressure (DBP) (MD: −1.96, p = 0.03). No significant association was found between ginseng dose and the magnitude of BP- lowering effect. However, a significant positive relationship was observed between baseline SBP level and the magnitude of SBP reduction (r = 0.848, p = 0.033). Such a relationship was not seen in DBP. Conclusion: Consumption of ginseng for 8-12 weeks achieved significant reductions in SBP and DBP in a dose-independent way. There was a significant positive relationship between baseline SBP level and the magnitude of SBP reduction.
목차
ABSTRACT
Materials and methods
Literature search
Study selection and data extraction
Assessment of risk of bias
Data synthesis and analysis
Results
Characteristics of the selected studies
The effect of ginseng on systolic blood pressure
The effect of ginseng on diastolic blood pressure
Comparison of the acute and long-term effect of ginseng on blood pressure
Assessment of risk of bias
Discussion
Conclusion
Conflicts of interest
References
키워드
American ginseng Korean red ginseng Korean white ginseng blood pressure randomized controlled trial저자
간행물 정보
발행기관
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- 발행기관명
- 한국임상약학회 [Korean College of Clinical Pharmacy]
- 설립연도
- 1
- 분야
- 의약학>약학
- 소개
- 합리적 약물치료(rational pharmacotherapy)의 보장 및 증진을 궁극목적으로 하며 이를 달성하기 위해 임상약학의 발전과 회원 상호간의 친목을 도모한다.
간행물
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- 간행물명
- 한국임상약학회지 [Korean Journal of Clinical Pharmacy]
- 간기
- 계간
- pISSN
- 1226-6051
- 수록기간
- 1991~2026
- 등재여부
- KCI 등재
- 십진분류
- KDC 518 DDC 615
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