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Original Article

Low estrogen levels and obesity are associated with shorter telomere lengths in pre- and postmenopausal women

첫 페이지 보기
  • 발행기관
    한국운동재활학회 바로가기
  • 간행물
    JER KCI 등재 바로가기
  • 통권
    Vol.12 No.3 (2016.06)바로가기
  • 페이지
    pp.238-246
  • 저자
    Yun-A Shin, Kyoung-Young Lee
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A278723

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원문정보

초록

영어
The aim of this study was to determine whether there is an association between leukocyte telomere length (LTL), and estrogen level, oxidative stress, cardiovascular disease (CVD) risk factors, and cardiorespiratory fitness (CRF) in pre- and postmenopausal obese women. Fifty-four obese women (premenopausal, n=25; postmenopausal, n=29) were selected to participate in this study. The outcome measurements in the pre- and postmenopausal groups were compared using independent t-tests and Pearson correlation analysis. The estrogen level (P<0.001), LTL (P<0.05), high-density lipoprotein level (P<0.05), and CRF (P<0.001) were higher in premenopausal women than in postmenopausal wom-en. The body fat percentage (P<0.05) and triglyceride concentration (P<0.05) were lower in premenopausal women than in postmenopaus-al women. There were no significant associations between LTL, CVD risk, CRF, and oxidative stress and antioxidant enzyme activity in pre-menopausal women. The body mass index (BMI) and body fat percent-age in postmenopausal women were negatively associated with LTL (P<0.05). When all women were considered (i.e., both pre- and post-menopause), the BMI, percentage of fat, and waist circumference had a negative association with LTL (P<0.05), and estrogen levels were positively associated with LTL (P<0.05). Decreased estrogen levels af-ter menopause, a pivotal factor in the biology of aging, and obesity were more associated with shorter telomere lengths in pre- and postmeno-pausal women than aerobic capacity and other CVD risk factors.

목차

ABSTRACT
 INTRODUCTION
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 CONFLICT OF INTEREST
 REFERENCES

키워드

Telomere Menopause Obesity Estrogen Cardiovascular disease risk factors

저자

  • Yun-A Shin [ Department of Prescription and Rehabilitation, College of Sports Science, Dankook University, Cheonan, Korea, Department of Kinesiologic Medical Science, Graduate School Dankook University, Cheonan, Korea ] Corresponding author
  • Kyoung-Young Lee [ Obesity Institute, Benessere Diet Center, Seoul, Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국운동재활학회 [Korean Society of Exercise Rehabilitation]
  • 설립연도
    2004
  • 분야
    의약학>재활의학
  • 소개
    한국운동재활학회는 사회적, 정신적, 신체적 통합건강복지 이론의 학술연구와 회원 상호간 학술교류 증진을 장려함으로써 학문적 발전을 도모하고 나아가 건강복지선진국 발전에 이바지함을 목적으로 한다.

간행물

  • 간행물명
    JER [Journal of Exercise Rehabilitation]
  • 간기
    격월간
  • pISSN
    2288-176X
  • eISSN
    2288-1778
  • 수록기간
    2013~2026
  • 등재여부
    SCOPUS,KCI 등재
  • 십진분류
    KDC 517 DDC 613

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