Earticle

초록

영어

Physical exercise is one of the most effective methods for managing obesity, and exercise exerts positive effects on various brain functions. Excessive weight gain is known to be related to the impairment of cog-nitive function. High-fat diet-induced obesity impairs hippocampal neu-roplasticity, which impedes cognitive function, such as learning ability and memory function. In this study, we investigated the effect of tread-mill exercise on impairment of cognitive function in relation with hippo-campal neuroplasticity using high-fat diet-induced obese mice. After obesity was induced by a 20-week high-fat (60%) diet, treadmill exer-cise was performed for 12 weeks. In the present results, cognitive func-tion was impaired in the high-fat diet-induced obese mice. Brain-de-rived neurotrophic factor (BDNF) and tyrosin kinase B (TrkB) expression and cell proliferation were decreased in the high-fat diet-induced obese mice. Treadmill exercise improved cognitive function through enhanc-ing neuroplasticity, including increased expression of BDNF and TrkB and enhanced cell proliferation. The present results suggest that tread-mill exercise enhances hippocampal neuroplasticity, and then potential-ly plays a protective role against obesity-induced cognitive impairment.

목차

ABSTRACT
 INTRODUCTION
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 CONFLICT OF INEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Tae-Woon Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Hyun-Hee Choi [ Division of Leisure & Sports Science, Department of Exercise Prescription, Dongseo University, Busan, Korea ]
• Yong-Rak Chung [ Department of Golf Mapping, College of Arts Physical Education, Joongbu University, Geumsan, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613