Earticle

초록

영어

Gabapentin, 1-(aminomethyl-1-cyclohexyl)acetic acid, is anew antiepileptic drug related to acid(GABA) currently being introduced in therapy worldwide. The bioavailability and pharmacokinetics of gabapentin capsules were examined in 22 volunteers who received a single oral dose in the fasting state by randomized balanced crossover design. After dosing, blood samples were collected for a period of 24 hours and analyzed by liquid chromatography-tandem mass spectrometry (LC/MS/MS). Time course of plasma gabapentin concentration was analyzed with non-compartmental and compartmental approaches. , the kinetic computer program, was used for compartmental analysis. One compartment model with first-order input, first-order output with no lag time and weighting by was chosen as the most appropriate pharmacokinetic model for the volunteers. The major pharmacokinetic parameters and other parameters of (test drug) and (reference drug) were estimated by non-compartmental analysis and compartmental analysis. The 90% confidence intervals of mean difference of logarithmic transformed were , respectively. It shows that the bioavailability of the test drug is equivalent with that of the reference drug. There was no statistically significant difference between the two drugs in all pharmacokinetic parameters.

목차

영문초록
 실험재료 및 방법
 실험결과 및 고찰
 결 론
 참고문헌

키워드

저자

• 정지훈 [ Jihoon Jeong | 충남대학교 약학대학 임상약학 연구실 ]
• 권준택 [ Jun-Tack Kwon | 순천향대학교 의과대학 임상약리학 연구실 ]
• 윤휘열 [ Hwi-yeol Yun | 충남대학교 약학대학 임상약학 연구실 ]
• 강원구 [ Wonku Kang | 대구 카톨릭대학교 약학대학 임상약학 연구실 ]
• 권광일 [ Kwang-il Kwon | 충남대학교 약학대학 임상약학 연구실 ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615