Earticle

초록

영어

The stability of cefditoren in three kinds of oral liquid preparations at 4 and was studied for 90 days. Two tablets of 100 mg cefditoren pivoxil were mixed with 200 mL of each oral liquid syrup, which is Pebron syrup (oxolamine citrate 10 mg/mL), syrup (ambroxol hydrochloride 3 mg/mL) or suspension (acetaminophen encapsulated 32 mg/mL). Three samples of each formulation were refrigerated and three were stored at room temperature . At predetermined time, samples were assayed by stability-indicating HPLC method. The chromatographic analysis after deliberate degradation showed no evidence of any breakdown product likely to interfere with the chromatographic peak of the parent substance. The relation between cefditoren pivoxil concentration and peak area was linear from 10 to . The analysis method was precise, with coefficients of variation no greater than 3.6%. Cefditoren was stable in syrup up to 4 weeks regardless of the temperature; in suspension and Pebron syrup, it was stable for at least 28 and 45 days, and 7 and 45 days at 25 and , respectively. The percentages of initial cefditoren concentration remaining after 90 days were in syrup, suspension and syrup at 25 and , respectively. The pH variations of all test solutions were minimal, which was within 0.5. The results indicated that the stability of cefditoren was significantly affected by liquid solutions mixed with cefditoren, and storage tempertature.

목차

영문초록
 실험재료및 방법
 실험결과
 고 찰
 결 론
 감사의 말씀
 참고문헌

키워드

저자

• 김혜경 [ Hye-Kyung Kim | 이화여자대학교 임상보건과학대학원 ]
• 곽혜선 [ Hye-Sun Gwak | 이화여자대학교 약학대학 ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615