Earticle

초록

영어

Diagnosis of cancer with biomarkers is relatively simple with the use of blood samples, and it can detect cancer at an early stage with expense compared to the other diagnosis methods. We use word embedding to find an alternative biomarker for the early diagnosis of ovarian cancer from the biomedical corpus. Word embedding is a word vector representation with previously proven efficiency in the biomedical domain. First, we derived a low dimensional representation of each biomarker embedding induced from Canonical Correlation Analysis (CCA), which is a powerful and flexible statistical technique for dimensionality reduction. Second, we found a similar pair of biomarkers in the literature by using cosine similarity of biomarker embedding. In order to determine the clinical similarity between the pair of biomarkers, we used the area under the curve (AUC) of the combination of 2 biomarkers used previously. In the experiment, we confirmed that correlation between the high similarity biomarker pair, was highly correlated as the average 0.710 of the actual AUC correlation of the top 10% of the pair.

목차

Abstract
 1. Introduction
 2. Data
 3. Methods
  3.1. Canonical Correlation Analysis (CCA)
  3.2. Inducing Biomarker Embedding
  3.3. Embedding Cosin Similarity
  3.4. AUC Correlation among the Combination of 2 Biomarkers
 4. Results
 5. Conclusion
 Acknowledgments
 References

키워드

저자

• Kyeong-Min Nam [ Department of Convergence Software, Hallym University 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702 Korea, Bio-IT Research Center, Hallym University, 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702 Korea ]
• Hey-Jung Song [ Department of Convergence Software, Hallym University 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702 Korea, Bio-IT Research Center, Hallym University, 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702 Korea ]
• Jong-Dae Kim [ Department of Convergence Software, Hallym University 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702 Korea, Bio-IT Research Center, Hallym University, 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702 Korea ]
• Can-Young Park [ Department of Convergence Software, Hallym University 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702 Korea, Bio-IT Research Center, Hallym University, 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702 Korea ]
• Yu-Seop Kim [ Department of Convergence Software, Hallym University 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702 Korea, Bio-IT Research Center, Hallym University, 1 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702 Korea ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  International Journal of Software Engineering and Its Applications

• 간기

  월간

• pISSN

  1738-9984

• 수록기간

  2008~2016

• 등재여부

  SCOPUS

• 십진분류

  KDC 505 DDC 605