Kim, H. J, K. Naruse, S. M. Chang, K. S. Im, S. H. Lee, C. S. Park, D. I. Jin
언어
영어(ENG)
URL
https://www.earticle.net/Article/A26978
※ 기관로그인 시 무료 이용이 가능합니다.
4,000원
원문정보
초록
영어
Transgenic mice containing GH Receptor (GHR) gene fused to metallothionein promoter were analyzed to evaluate effect of GHR expression on growth in vivo. Three founder mice lines contained copies of GHR transgene and transmitted these genes into F₁ and F₂ progenies. The mRNA expression of transgene was identified using RT-PCR with GHR genes in tissues. To analyze the effects of transgenes on growth performance, body weights of pups were measured at 4, 10 and 14 weeks after birth. The body weight of transgenic mice was higher compared with that of non-transgenic control mice regardless of sex (P<0.05). Body weights between transgenic and non-transgenic mice were increased with aging. Overall, GHR transgenic mice tended to grow about 10 to 15 % faster than non-transgenic mice without any pathological defects.