Because of global climate change, mosquitos which are vectors for the dengue virus (DENV) are increasing in population and the incidence of dengue fever and dengue hemorrhagic fever is increasing every year in countries not only in the subtropics but also in other regions worldwide. There are 4 subtypes of DENV, each differing in infectivity and virulence. This study compared and analyzed genetic variation in the genomic sequences of DENV subtypes 1 and 2. The results showed that while non-synonymous codon variation was high in DENV-1, synonymous codon variation was also high in DENV-2. Additionally, there were differences in the genetic variation in each subtype according to the year or region, and incidence levels increased during periods when sequence variation was high. The results of this study can be used to compare the subtype-specific genetic variation characteristics of DENV to predict the incidence rates and sequence variations of DENV according to the region or year.
목차
Abstract 1. Introduction 2. Materials and Methods 2.1 Collection of Nucleotide Sequence 2.2 Phylogenetic Analysis 2.3 Comparison of Codon Substitution Pattern 3. Results 4. Discussion and Conclusions References
Jin-Hwa Jang [ Biomedical Prediction Technology Laboratory, Korea Institute of Science and Technology Information, Laboratory of Computational Biology and Bioinformatics, Institute of Public Health and Environment, Graduate School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea ]
Youngmahn Han [ Biomedical Prediction Technology Laboratory, Korea Institute of Science and Technology Information, 245 Daehak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea ]
Insung Ahn [ Biomedical Prediction Technology Laboratory, Korea Institute of Science and Technology Information, 245 Daehak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea ]
Corresponding Author
보안공학연구지원센터(IJBSBT) [Science & Engineering Research Support Center, Republic of Korea(IJBSBT)]
설립연도
2006
분야
공학>컴퓨터학
소개
1. 보안공학에 대한 각종 조사 및 연구
2. 보안공학에 대한 응용기술 연구 및 발표
3. 보안공학에 관한 각종 학술 발표회 및 전시회 개최
4. 보안공학 기술의 상호 협조 및 정보교환
5. 보안공학에 관한 표준화 사업 및 규격의 제정
6. 보안공학에 관한 산학연 협동의 증진
7. 국제적 학술 교류 및 기술 협력
8. 보안공학에 관한 논문지 발간
9. 기타 본 회 목적 달성에 필요한 사업
간행물
간행물명
International Journal of Bio-Science and Bio-Technology
간기
격월간
pISSN
2233-7849
수록기간
2009~2016
등재여부
SCOPUS
십진분류
KDC 505DDC 605
이 권호 내 다른 논문 / International Journal of Bio-Science and Bio-Technology Vol.7 No.6