Earticle

초록

영어

Glucose is universal and essential fuel of energy metabolism and in the synthesis pathways of all mammalian cells. Glucose is the one of the major precursors of lactose synthesis using glycolysis result in producing milk fat and protein. During the milk fat synthesis, lipoprotein lipase (LPL) and CD36 are required for glucose uptake. Various morecules such as acyl-CoA synthetase 1 (ACSL1) activity of acetyl-CoA synthetase 2 (ACSS2), ACACA, FASN AGPAT6, GPAM, LPIN1 are closely related with milk fat synthesis. Additionally, glucose plays a major role for synthesizing lactose. Activations of lactose synthesize enzymes such as membranebound enzyme, beta-1,4- galactosyl transferase (B4GALT), glucose-6-phosphate dehydrogenase (G6PD) are changed by concentration of glucose in blood resulting change of amount of lactose production. Glucose transporters are a wide group of membrane proteins that facilitate the transport of glucose over a plasma membrane. There are 2 types of glucose transporters which consisted facilitative glucose transporters (GLUT); and sodium-dependent transport, mediated by the Na+/glucose cotransporters (SGLT). Among them, GLUT1, GLUT8, GLUT12, SGLT1, SGLT2 are main glucose transporters which involved in mammary gland development and milk synthesis. However, more studies are required for revealing clear mechanism and function of other unknown genes and transporters. Therefore, understanding of the mechanisms of glucose usage and its regulation in mammary gland is very essential for enhancing the glucose utilization in the mammary gland and improving dairy productivity and efficiency.

목차

ABSTRACT
 INTRODUCTION
 FUNCTION OF GLUCOSE IN MAMMARY GLAND DURING LACTATION
 EFFECTS OF GLUCOSE ON MILK FAT SYNTHESIS BY REGULATING KEY GENES
 EFFECTS OF GLUCOSE ON MRNA EXPRESSION OF THE KEY GENES WHICH REGULATE LACTOSE SYNTHESIS
 FUNCTION OF GLUCOSE ON GLUCOSE METABOLISM
 GLUCOSE TRANSPOTERS
 MAJOR REGULATORY GLUCOSE TRANSPORTERS IN BOVINE MAMMARY GLAND
 CONCLUSION

키워드

저자

• Young-Tae Heo [ Department of Animal Biotechnology, College of Animal Bioscience and Technology, Konkuk University, Seoul 05029, Republic of Korea ]
• Joung-Jun Park [ Animal Reproduction Biotechnology Center, Hoengseong 25232, Republic of Korea ]
• Hyuk Song [ Department of Animal Biotechnology, College of Animal Bioscience and Technology, Konkuk University, Seoul 05029, Republic of Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Reproductive & developmental biology

• 간기

  계간

• pISSN

  1738-2432

• eISSN

  2288-0151

• 수록기간

  1977~2018

• 십진분류

  KDC 527 DDC 636