Earticle

초록

영어

Objective: It is to evaluate the drug interaction monitoring program as a pilot project to develop a pharmaceutical care model in a medical intensive care unit and to analyze the influencing factors of drug interactions. Method: Electronic medical records were retrospectively investigated for 116 patients who had been hospitalized in a medical intensive care unit from October to December in 2014. The prevalence of adverse reaction with risk rating higher than ‘D’ was investigated by Lexi-Comp® Online database. The factors related with potential drug interaction and with treatment outcomes were analyzed. Results: The number of patients with a potential interaction of drug combination was 92 (79.3%). Average ages, the length of stay in the intensive care unit and the numbers of prescription drugs showed significant differences between drug interaction group and non-drug interaction group. Opioids (14.4%), antibiotics (7.2%), and diuretics (7.2%) were most responsible drug classes for drug interactions and the individual medications included furosemide (6.4%), tramadol (4.9%), and remifentanil (4.5%). There were 950 cases with a risk rating of ‘C’ (84.6%), 142 cases with a risk rating of ‘D’ (12.6%), and 31 cases with a risk rating of ‘X’ (avoid combination) (2.8%). The factors affecting drug interactions were the number of drugs prescribed (p < 0.0001) and the length of stay at intensive care unit (p < 0.01). The patients in intensive care unit showed a high incidence of adverse reactions related to potential drug interaction. Therefore, drug interaction monitoring program as a one of pharmaceutical care services was successfully piloted and it showed to prevent adverse reaction and to improve therapeutic outcomes. Conclusion: Active participation of a pharmacist in the drug management at the intensive care unit should be considered.

목차

ABSTRACT
 연구 방법
  연구대상 및 자료수집
  연구도구 및 분석방법
 연구 결과
  대상환자군의 특성
  잠재적 약물상호작용의 위험도별 현황
  잠재적 약물상호작용의 영향인자
  치료성과와 잠재적 약물상호작용의 관련성
  잠재적 약물상호작용 중 이상반응 발현의 예와 중등도 분석
 고찰 및 결론
 참고문헌

키워드

저자

• 최재희 [ Jae Hee Choi | 이화여자대학교 임상보건과학대학원, 건국대학교병원 약제부 ]
• 최경숙 [ Kyung Sook Choi | 분당서울대학교병원 약제부, 이화여자대학교 약학대학 ]
• 이광섭 [ Kwang Seup Lee | 건국대학교병원 약제부 ]
• 이정연 [ Sandy Jeong Rhie | 이화여자대학교 임상보건과학대학원, 이화여자대학교 약학대학 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615