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제 2형 당뇨병 환자의 유방암 발생 위험 및 사망률에 대한 메트포민의 영향 : 체계적 문헌고찰 및 메타분석
Effects of Metformin on Breast Cancer Risk and Mortality in Type 2 Diabetes Mellitus : A Systematic Review and Meta-analysis
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- 발행기관
- 한국임상약학회 바로가기
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- 간행물
- 한국임상약학회지 KCI 등재 바로가기
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- 통권
- 제25권 제3호 (2015.09)바로가기
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- 페이지
- pp.131-137
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A255270
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4,000원
원문정보
초록
- 영어
- Background: The protective effect of metformin against breast cancer is inconclusive. Objective: To evaluate the effect of metformin on breast cancer risk and mortality in patients with type 2 diabetes. Method: A comprehensive literature search was performed for pertinent articles published prior to June 30, 2014, using PubMed and EMBASE. Study heterogeneity was estimated with I2 statistic. The data from the included studies were pooled and weighted by random-effects model. The quality of each included study was assessed on the basis of the 9-star Newcastle-Ottawa Scale and publication bias was evaluated by visual inspection of a funnel plot. Results: Ten studies were included in the meta-analysis of the association of metformin and breast cancer risk. By synthesizing the data from the studies, the pooled odds ratio (OR) was 0.72 (95% CI: 0.59, 0.87) (p = 0.0005). Three cohort studies were included for meta-analysis of the association between metformin and breast cancer- related mortality. Metformin was associated with a significant decrease in mortality (Risk ratio: 0.68; 95% CI: 0.51, 0.90, p = 0.007). Conclusion: The present metaanalysis suggests that metformin appears to be associated with a lower risk of breast cancer incidence and mortality in patients with type 2 diabetes.
목차
ABSTRACT
Introduction
Methods
Data sources and searches
Study selection
Data extraction and quality assessment
Data synthesis and analysis
Results
The effect of metformin therapy on breast cancer risk
The effect of metformin use on breast cancer-relatedmortality
Discussion
Conclusion
Acknowledgement
References
키워드
breast cancer breast neoplasm metformin biguanide diabetes mellitus저자
간행물 정보
발행기관
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- 발행기관명
- 한국임상약학회 [Korean College of Clinical Pharmacy]
- 설립연도
- 1
- 분야
- 의약학>약학
- 소개
- 합리적 약물치료(rational pharmacotherapy)의 보장 및 증진을 궁극목적으로 하며 이를 달성하기 위해 임상약학의 발전과 회원 상호간의 친목을 도모한다.
간행물
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- 간행물명
- 한국임상약학회지 [Korean Journal of Clinical Pharmacy]
- 간기
- 계간
- pISSN
- 1226-6051
- 수록기간
- 1991~2026
- 등재여부
- KCI 등재
- 십진분류
- KDC 518 DDC 615
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