Earticle

초록

영어

Brain-derived neurotrophic factor (BDNF) and its receptors tyrosine ki-nase B (trkB), and cyclic adenosine monophosphate response element binding protein (CREB) have been suggested as the neurobiological risk factors causing depressive disorder. Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the pathogenesis of depression. We in-vestigated the effect of treadmill exercise on social interaction in rela-tion with BDNF and 5-HT expressions following stress in rats. Stress was induced by applying inescapable 0.2 mA electric foot shock to the rats for 7 days. The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 4 weeks. Social interaction test and western blot for BDNF, TrkB, pCREB, and 5-HT1A in the hippo-campus were performed. The results indicate that the spend time with unfamiliar partner was decreased by stress, in contrast, treadmill exer-cise increased the spending time in the stress-induced rats. Expres-sions of BDNF, TrkB, and pCREB were decreased by stress, in contrast, treadmill exercise enhanced expressions of BDNF, TrkB, and pCREB in the stress-induced rats. In addition, 5-HT1A receptor expression was de-creased by stress, in contrast, treadmill exercise enhanced 5-HT1A ex-pression in the stress-induced rats. In the present study, treadmill exer-cise alleviated stress-induced social interaction impairment through enhancing hippocampal plasticity and serotonergic function in the hip-pocampus. These effects of treadmill exercise are achieved through 5-HT1A receptor activation.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Induction of stress
  Exercise protocol
  Social interaction test
  Western blot for BDNF, TrkB, pCREB, and 5-HT
  Data analysis
 RESULTS
  Effect of treadmill exercise on social interaction
  Effect of treadmill exercise on BDNF and TrkB expressions in hippocampus
  Effect of treadmill exercise on pCREB expression in hippocampus
  Effect of treadmill exercise on 5-HT1A expression in hippocampus
 DISCUSSION
 REFERENCES

키워드

저자

• Tae-Woon Kim [ Department of Physiology, Kyung Hee University School of Medicine, Seoul, Korea ]
• Baek-Vin Lim [ Department of Exercise Prescription, Division of Leisure & Sports Science, Dongseo University, Busan, Korea ]
• Kijeong Kim [ Department of Exercise & Sport Science, College of Natural Sciences, University of Ulsan, Ulsan, Korea ]
• Jin-Hee Seo [ Division of Sports Science, Baekseok University, Cheonan, Korea ]
• Chang-Ju Kim [ Department of Physiology, Kyung Hee University School of Medicine, Seoul, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613