Earticle

초록

영어

We induced middle cerebral artery occlusion (MCAO) in rats using sili-cone-coated vascular embolus. We transplanted mouse embryonic stem (mES) cells after MCAO. Rats were tested behaviorally using mo-tor and sensory function with neurological assessment. Functional ef-fectiveness of the transplanted mES cells gradually improved the func-tion of sensory and motor neurons. This study demonstrated that the transplanted cells have synaptic connection in the recipient brain. We suggest that stem cell transplantation can have a positive effect on be-havioral recovery and reduction of infarct size in focal ischemic rats. Cell transplantation may induce certain functional recovery of the brain tissue by endogenous cell mediated effect. Our study suggests that in-tracerebrally injected mES cells survived and migrated into the infarct area from inoculation site and neuroglially differentiated in the ischemic brain area of adult rats. Therefore, mES cells may be a useful tool for the treatment in neurological diseases. In conclusion, cell transplanta-tion therapy represents a novel approach that may enhance the effica-cy and effectiveness of stem cell transplantation after ischemic stroke.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animal model
  Preparation of mouse embryonic cell
  Cerebral ischemic model
  Transplantation procedure and staining
  Statistical analysis
 RESULTS
  fMRI characteristics of infarction region
  Localization of ischemic lesion
  Assessment of behavioral function
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Tae Hoon Lee [ Department of Emergency Medical Service, Namseoul University, Cheonan, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613