Earticle

초록

영어

Maternal stress during pregnancy affects negative impact on health of offspring. In the present study, we compared the effects of maternal treadmill exercise and offspring treadmill exercise on prenatal stress-induced apoptosis and serotonin expression in offspring. Stress to the pregnant rats was induced by exposure of maternal rats to the hunting dog in an enclosed room. Exposure time was 10 min, three times per day, with a 1-h interval between exposures. This regimen was maintained from the seventh day of gestation until delivery. The preg-nant rats in the exercise group were forced to run on a motorized tread-mill for 30 min once a day, started 7 days after pregnancy until delivery. The offspring in the exercise group were forced to run on a motorized treadmill for 30 min once a day, started 4 weeks after birth for 4 weeks. In the present results, offspring exposed to prenatal stress exhibited lower Bcl-2 level and higher Bax level in the hippocampus, lower 5-hy-droxytryptamine (5-HT) and tryptophan hydroxylase (TPH) expression in the dorsal raphe, and higher c-Fos expression in the locus coeruleus compared to age-matched control rats. Treadmill exercise of offspring suppressed Bax expression and enhanced Bcl-2 expression in the hip-pocampus, increased 5-HT and TPH expression in the dorsal raphe, and enhanced c-Fos expression in the locus coeruleus of offspring. Tread-mill exercise of offspring suppressed prenatal stress-induced apoptosis and normalized prenatal stress-induced alterations in serotonin synthe-sis and neuronal activation. However maternal treadmill exercise during pregnancy exerted no significant effect on offspring.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Induction of stress during pregnancy
  Exercise protocol
  Tissue preparation
  Western blot for Bax and Bcl-2
  Immunohistochemistry for 5-HT and TPH
  Immunohistochemistry for c-Fos
  Data analysis
 RESULTS
  Effect of treadmill exercise on Bax and Bcl-2 expression in the hippocampus
  Effect of treadmill exercise on 5-HT expression in the dorsal raphe
  Effect of treadmill exercise on TPH expression in the dorsal raphe
  Effect of treadmill exercise on c-Fos expression in the locus coeruleus
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• Tae-Woon Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul. Korea ]
• Eun-Sang Ji [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul. Korea ]
• Tae-Wook Kim [ Department of Community Sport and Recreation. College of Health Science. Jangan University, Hwasung, Korea ]
• Sang-Won Lee [ Department of Physical Education, Korea Military Academy, Seoul, Korea ]
• Choong-Yeol Lee [ Department of Oriental Physiology, Gachon University College of Oriental Medicine, Seongnam, Korea ]
• Sam-Jun Lee [ Department of Physical Education, College of Health, Welfare. and Education, Tong Myong University, Susan, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613