Earticle

초록

영어

Huntington's disease (HD) is an inherited genetic disorder, characterized by cognitive dysfunction and abnormal body movements called chorea. Quinolinic acid (QA) is an endogenous metabolite oftryptophan in the kynurenine pathway. QA-induced alterations are similar to the symptoms of HD patients. Physical exercise has beneficial effects on the brain functions. Exercise increases production of neurotrophic factors in the brain and improves learning ability and memory function. In the present study, we investigated the effects of treadmill exercise short-term memory on QA-induced HD rats in relation with cell proliferation. For the induction of Huntington's animal model, 2 uL of 100 nmol QA was intrastriatal injected into the rats. The rats in the treadmill exercise groups were forced to run on a treadmill for 30 min once a day, five times a week for 2 weeks. Step-down avoidance test was conducted for the determination of short-term memory. Cell proliferation in the hippocampal dentate gyrus was determined by 5-bromo-2'-deoxyuridine (BrdU) and double cortin (DCX) immunohistochemistry. Western blot for brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) were performed. In the present results, treadmill exercise alleviated QA-induced short-term memory impairment in HD rats. Treadmill exercise increased cell proliferation in the hippocampal dentate gyrus through enhancing BDNF expression in the HD rats. These results revealed that treadmill exercise is effective for the symptom improvement in the HD patients.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Induction of HD model
  Treadmill exercise protocol
  Step-down avoidance test
  Tissue preparation
  BrdU immunohistochemistry
  DCX immunohistochemistry
  Western blot analysis BDNF and Trk-B
  Data analysis
 RESULTS
  Effect of treadmill exercise on the short-term memory in the step-down avoidance test
  Effect of treadmill exercise on the hippocampal neurogenesis
  Effect of treadmill exercise on the hippocampal neuronal marker
  Effect of treadmill exercise on the BDNF and Trk Bexpression in the hippocampus
 DISCUSSION
 CONFLICT OF INTEREST
 ACKNOWLEDGMENTS
 REFERENCES

키워드

저자

• You-Mi Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Eun-Sang Ji [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea, Department of Sport & Health Science, College of Natural Science. Sangmyung University, Seoul, Korea ]
• Sang-Hoon Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea, Department of Sport & Health Science, College of Natural Science. Sangmyung University, Seoul, Korea ]
• Tae-Woon Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• ll-Gyu Ko [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Jun-Jang Jin [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Chang-Ju Kim [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Tae-Wook Kim [ Department of Community Sport and Recreation, College of Health Science, Jangan University, Hwasung, Korea ]
• Dong-Hee Kim [ Department of Ophthalmology, Chungju Hospital, College of Medicine, Konkuk University, Chungju, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613