Earticle

초록

영어

A number of studies have shown that the prevention and cure of malignant tumors may become much easier if growth mechanisms, such as the role of cleavage furrow formation in tumor cell division, could be discovered and understood in the earlier avascular phase. Although it is well known that metazoan mitotic spindle which is one of the most important substances during the cytokinesis of a cell division determines the position of the cleavage furrow formation, we are still on the verge of solving the puzzle of what molecules and how they control the formation of the cleavage furrow. In this paper, we propose a cleavage furrow formation approach based on finite element method, which combines nodes selection, mesh partition and matrix assembly in a total energy equation, for modeling the mechanisms of avascular tumor growth. We also perform several experiments. Results show that, by using our proposed approach for the avascular tumor growth, the positions of cleavage furrows are decided not only chemically but also physically and tumor cells are not symmetric, which demonstrates the effectiveness of our proposed approach.

목차

Abstract
 1. Introduction
 2. Finite Element Based Modeling
  2.1. Nodes Selection
  2.2. Mesh Partition
  2.3. Matrix Assembly
 3. Cleavage Furrow Formation
 4. Multi-cellular Tumor Growth
 5. Experiments
 6. Conclusion
 Acknowledgments
 References

키워드

저자

• Changyu Liu [ School of Computer Science and Engineering, South China University of Technology, Guangzhou 510006, China ]
• Dapeng Li [ College of Telecommunications and Information Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210003, China ] Corresponding author
• Bin Lu [ School of Computer Science, Wuyi University, Jiangmen 529020, China ]
• Tiezhu Zhao [ Computer College, Dongguan University of Technology, Dongguan 523808, China ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  International Journal of Multimedia and Ubiquitous Engineering

• 간기

  월간

• pISSN

  1975-0080

• 수록기간

  2008~2016

• 등재여부

  SCOPUS

• 십진분류

  KDC 505 DDC 605