Zhenglong Liu, Yanmei Yang, Yujun Luo, Hongping Wang
언어
영어(ENG)
URL
https://www.earticle.net/Article/A241957
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원문정보
초록
영어
A human chromosome is a DNA molecule with approximately 108 base pairs. The techniques developed to date for sequencing are restricted to pieces of DNA with up to tens of thousands of base pairs. This means that when a piece is sequenced, only an extremely small part of a chromosome can be seen. Molecular biologists use special techniques to deal with DNA molecules comparable in size to a chromosome. These techniques enable them to create maps of an entire chromosome or of significant fractions of chromosomes. Computational techniques were studied that could potentially aid biologists in the map-generation process. An algorithm that solves the consecutive 1s problem was studied. Such a problem is a good model of hybridization mapping when there are no errors and when probes are unique. If errors are present, another approach is needed, and the approximation algorithm is a prospective problem solver for hybridization physical mapping of DNA with errors.
목차
Abstract 1. Introduction 2. TSP Graph Model 2.1. Build DNA Physical Mapping Model 2.2. Minimum-weight Cycle Computation of G Graph 2.3. NP-hard Problem 3. Main Title Algorithm Feasibility Analysis 3.1. DNA Physical Mapping Probe Permutation 3.2. Clones x Probes Binary Matrix 3.3. Hybridization Probability Computational 4. Computational Practice 4.1. Hybridization Mapping Algorithms 4.2. Consecutive 1s Problem Feature 4.3. Greedy TSP and Random Algorithm Compare 4.4. Heuristics for Hybridization Mapping 4.5. Obtaining a Good Probe Ordering 4.6. DNA Physical Mapping Algorithm Design 4.7. Algorithm Implications 5. Conclusion Acknowledgements References
키워드
Physical MappingDNAHybridizationProbes matrixGreedy TSPConsecutive 1s Problem (C1P)
저자
Zhenglong Liu [ Department of Mathematics and Computer of North-SiChuan Medical College, NanChong, SiChuan, 637007, China ]
Yanmei Yang [ Mathematics & Information College of West China Normal Unvisersity NanChong, SiChuan, 637003, China ]
Yujun Luo [ Department of Mathematics and Computer of North-SiChuan Medical College, NanChong, SiChuan, 637007, China ]
Corresponding Author
Hongping Wang [ Department of information management, Nanchong Professional Technic College, NanChong, SiChuan,China 637007) ]
보안공학연구지원센터(IJHIT) [Science & Engineering Research Support Center, Republic of Korea(IJHIT)]
설립연도
2006
분야
공학>컴퓨터학
소개
1. 보안공학에 대한 각종 조사 및 연구
2. 보안공학에 대한 응용기술 연구 및 발표
3. 보안공학에 관한 각종 학술 발표회 및 전시회 개최
4. 보안공학 기술의 상호 협조 및 정보교환
5. 보안공학에 관한 표준화 사업 및 규격의 제정
6. 보안공학에 관한 산학연 협동의 증진
7. 국제적 학술 교류 및 기술 협력
8. 보안공학에 관한 논문지 발간
9. 기타 본 회 목적 달성에 필요한 사업
간행물
간행물명
International Journal of Hybrid Information Technology
간기
격월간
pISSN
1738-9968
수록기간
2008~2016
십진분류
KDC 505DDC 605
이 권호 내 다른 논문 / International Journal of Hybrid Information Technology Vol.8 No.2