Earticle

초록

영어

DNA microarray technique can detect tens of thousands of genes activity in cells and has been widely used in clinical diagnosis. However, microarray data has the characteristics of high dimension and small samples, moreover many irrelevant and redundant genes also decrease performance of classification algorithm. Feature gene selection is an effective method to solve this problem. This paper proposes a hybrid feature gene selection method. Firstly, a lot of irrelevant genes from original data were eliminated by using reliefF algorithm, and the candidate feature genes subset is obtained; Secondly, Fuzzy neighborhood rough set with information entropy which deals directly with continuous data is proposed to reduce redundant genes among genes subset above. Here, differential evolution algorithm is used to optimize radius before reduction by using fuzzy neighborhood rough set, because radius of neighborhood greatly affects reduction performance. The simulation results on six microarray datasets indicate that our method can obtain higher classification accuracy by using as few genes as possible, especially feature genes selected are important for understanding microarray data and identifying the pathogenic genes. The results demonstrated that this method is effective and efficient for feature genes selection.

목차

Abstract
 1. Introduction
 2. ReliefF Algorithm
 3. Fuzzy Neighborhood Rough Set based on Information Entropy
  3.1 Neighborhood Rough Set (NRS)
  3.2. Fuzzy Neighborhood Rough set (FNRS)
  3.3. Attribute Reduction Algorithm based on Fuzzy Neighborhood Rough Set with Information Entropy and Forward Greedy Search Strategy
 4. Differential Evolution Algorithm
 5. Our Proposed Method
 6. Experimental Results and Analysis
  6.1. Experimental Datasets
  6.2 Experimental Results and Analysis
 7. Conclusion
 Acknowledgements
 References

키워드

저자

• Tao Chen [ School of Automation, Northwestern Polyechnical University, Xi’an, Shaanxi, 710072, China, School of Mathematics and Computer Science, Shaanxi University of Technology, Hanzhong, 723000, Shaanxi, China ]
• Zenglin Hong [ School of Automation, Northwestern Polyechnical University, Xi’an, Shaanxi, 710072, China ]
• Fang-an Deng [ School of Mathematics and Computer Science, Shaanxi University of Technology, Hanzhong, 723000, Shaanxi, China ]
• Man Cui [ School of Automation, Northwestern Polyechnical University, Xi’an, Shaanxi, 710072, China ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  International Journal of Signal Processing, Image Processing and Pattern Recognition

• 간기

  격월간

• pISSN

  2005-4254

• 수록기간

  2008~2016

• 십진분류

  KDC 505 DDC 605