Earticle

초록

영어

There are many mathematical models or chemical models available to describe the avascular tumor growth. However, few of them take into account the necessary physical growth for the avascular tumor. In this paper, we proposed a multiscale finite element model that spans three distinct scales for the avascular tumor growth. At the extracellular microenvironment level, we proposed a new set of piecewise reaction diffusion equations to describe the extracellular microenvironment of the tumor growth. At the intracellular cycle level, we proposed a cell cycle control factor to model the key role that played by the G1-S phase transition. At the cellular level, we introduced the proposed cell cycle control factor to combine the extracellular microenvironment, the intracellular cycle and the cellular cycle into the total energy equations to form our finite element cellular model. Experiments were performed to simulate the growth of EMT6/Ro mouse mammary cell under three different kinds of initial chemical concentrations. Results showed that the proposed approach outperformed the baseline approach in terms of tumor cell number and tumor cell volume.

목차

Abstract
 1. Introduction
 2. Finite Element Based Multiscale Modeling
  2.1. Basic Assumptions
  2.2. Extracellular Microenvironment Level
  2.3. Intracellular Cycle Level
  2.4. Cellular Level
 3. Experiments
  3.1. Simulation Process
  3.2. Simulation Conditions
  3.3. Results for Extracellular Microenvironment Level
  3.4. Results for Intracellular Cycle Level
  3.5. Results for Cellular Level
 4. Conclusion
 Acknowledgments
 References

키워드

저자

• Changyu Liu [ School of Computer Science and Engineering, South China University of Technology, Guangzhou 510006, China, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA ]
• Changyu Liu [ School of Computer Science and Engineering, South China University of Technology, Guangzhou 510006, China, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA ]
• Bin Lu [ School of Computer Science, Wuyi University, Jiangmen 529020, China ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  International Journal of Control and Automation

• 간기

  월간

• pISSN

  2005-4297

• 수록기간

  2008~2016

• 십진분류

  KDC 505 DDC 605